ISSN:
1432-1440
Keywords:
Key words Nude mice
;
Transplantation
;
Epiphyseal growth plate
;
Ossification
;
Development of long bones
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract In a specific animal model the induction of heterologous enchondral ossification was examined in long term follow-up. Physiologically normal and devitalized frozen porcine epiphyseal cartilage as a control group were transplanted as s.c. xenograft into athymic nude mice (nu/nu). 15 weeks after transplantation the porcine growth plate cartilage showed the development of viable cartilage tissue in the recipients, further differentiating to juvenile longe bone with epiphysis, diaphysis and growth plate. Porcine growth plate cartilage increased s.c. in the recipient nude mice, showing enchondral ossification without any physiological load, and finally an unexpected development towards complete juvenile long bone.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/s001090050328
Permalink
