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  • 1
    Electronic Resource
    Electronic Resource
    Circadian rhythm in type I collagen formation in postmenopausal women with and without osteopenia (1995)
    Springer
    Osteoporosis international 5 (1995), S. 472-477 
    Details
    ISSN: 1433-2965
    Keywords: Circadian rhythm ; Cosinor analysis ; Osteopenia ; Postmenopause ; Procollagen type I carboxyl-terminal propeptide (PICP)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A circadian rhythm in the serum concentration of the procollagen type I carboxyl-terminal propeptide (sPICP) has previously been demonstrated in premenopausal women. This study was performed to investigate the circadian rhythm in sPICP in healthy and osteopenic postmenopausal women. Blood samples were taken every third hour for 27 h from three groups of women: 12 early postmenopausal women (aged 55±2 years; mean±SD); 12 late postmenopausal women (aged 73±1 years); and 12 osteopenic but otherwise healthy late postmenopausal women (aged 73±1 years). A circadian rhythm in sPICP was found in all three groups, as shown by cosinor analysis (p=0.000003−0.03). The circadian rhythm in sPICP was significantly different between the osteopenic group and the age-matched healthy group (p〈0.008). The amplitude of the circadian rhythm in sPICP was about twice as high in the osteopenic group, and the time of the maximum tended to be about 3 h later, as compared with the age-matched healthy group. The plasma concentration of osteocalcin, as measured by a recently developed two-site enzyme-linked immunosorbent assay, also showed a circadian rhythm in all three groups (p=0.0001−0.05), with no significant differences between groups. In conclusion, we have found a significant circadian rhythm in sPICP in both early and late postmenopausal women. In osteopenic women the nightly peak in sPICP is larger and persists later into the night as compared with non-osteopenic women.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01626611
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  • 2
    Electronic Resource
    Electronic Resource
    Serum concentration of vitamin D metabolites in rheumatoid arthritis (1987)
    Springer
    Clinical rheumatology 6 (1987), S. 238-243 
    Details
    ISSN: 1434-9949
    Keywords: Rheumatoid Arthritis ; Vitamin D Metabolism
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary One-hundred and two patients with rheumatoid arthritis (RA) were studied. They were divided into three groups according to treatment with gold salts, penicillamine or glucocorticoids. Blood samples were drawn between November and January and four different metabolites of vitamin D (25(OH)D3, 24,25 (OH)2D3, 25,26 (OH)2D and 1,25 (OH)2D) were measured and compared to values from normal subjects. The mean serum concentrations of 25(OH)D3 in all three patient groups were significantly lower than those of the controls (p〈0.01–0.001). The mean serum concentrations of 24,25 (OH)2D3 and 25,26 (OH)2D were not significantly different from the control values, whereas 1,25 (OH)2D concentrations were significantly lower in the penicillamine and steroid groups (p〈0.05–0.01). When patients were stratified according to functional classes, we found a significant inverse relation between serum concentrations of 25(OH) D3, 24,25(OH)2D3, 25,26(OH)2D and the functional class, but not between 1,25(OH)2D and the functional class. We conclude that the decreased serum 25(OH)D3 concentration found in patients with RA is likely to be caused by decreased exposure to sunlight due to decreased activity, and thus is a result of the disease rather than a pathogenetic factor. Whether the small decrease in serum 1,25(OH)2D is of clinical significance and related to the development of osteoporosis in patients with RA is probably doubtful.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02201030
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  • 3
    Electronic Resource
    Electronic Resource
    Relationship between local and total bone mineral in patients with rheumatoid arthritis and normal subjects (1983)
    Springer
    Clinical rheumatology 2 (1983), S. 265-271 
    Details
    ISSN: 1434-9949
    Keywords: Rheumatoid arthritis ; Total Body Bone Mineral ; Local Bone Mineral ; Osteopenia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Total body bone mineral (TBBM) measured by dual photon absorptiometry and local bone mineral (BMC) measured by single photon absorptiometry were determined in 55 patients with definite or classical rheumatoid arthritis. All of them had been on a steady dose of anti-inflammatory drugs for at least 12 months, and furthermore, 13 patients were on glucocorticoids. The results were compared with 49 normal persons matched for sex, age and menopausal state. A highly significant correlation was found between BMC and TBBM in the patients (r = 0.84, SEE = 13.0%) as well as in the controls (r = 0.77, SEE 10.5%). Moreover, the intercepts and the slopes were virtually of the same order. Subdividing the patients according to glucocorticoid treatment the same high correlations were shown in the two subgroups. As a group the patients on glucocorticoids had a highly significant generalized osteopenia (a reduction of TBBM of 26 % compared to normals). The patients on other anti-inflammatory drugs had a significant, but less pronounced generalized osteopenia (a reduction of TBBM by 11 % compared to normals). It is concluded, that BMC of the forearm can be used as a valid estimate of total body calcium in groups of patients with rheumatoid arthritis and in normal subjects.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02041401
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  • 4
    Electronic Resource
    Electronic Resource
    Prevalence of decreased bone mass in rheumatoid arthritis. Relation to anti-inflammatory treatment (1984)
    Springer
    Clinical rheumatology 3 (1984), S. 201-208 
    Details
    ISSN: 1434-9949
    Keywords: Bone Mineral Content ; Calcium Metabolism ; Prednisone ; Rheumatoid Arthritis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The bone mineral content (BMC) in both forearms (highly correlated to total body calcium) was measured by photon absorptiometry in a representative sample of rheumatoid arthritis outpatients comprising 129 patients treated with either gold salts (n=29), penicillamine (n=61), prednisone (n=24), or other anti-RA drugs (n=15). The mean BMC value was 84% of normal (p〈0.001) with the lowest mean value in the group treated with prednisone (73% of normal). The patients as a group had hypocalcaemia (p〈0.001), raised serum alkaline phosphatase (p〈0.001), and normal urinary excretion rates of calcium and hydroxyproline. These results indicate that RA patients have disturbances in their calcium and bone metabolism.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02030755
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    Paper (German National Licenses)
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