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  • 1
    Electronic Resource
    Electronic Resource
    Effects of oxyfedrine and ouabain on the heart-lung preparation of the dog (1973)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 277 (1973), S. 89-102 
    Details
    ISSN: 1432-1912
    Keywords: Oxyfedrine ; Ouabain ; Cardiotonic Effect ; Heart-Lung Preparation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The actions of l-3-methoxy-ω-(1-hydroxy-1-phenylisopropylamino) propiophenone hydrochloride (oxyfedrine) and ouabain in the canine heart-lung preparation (HLP) were studied taking particular notice of the changes of competence index and cardiac output. Both of these drugs caused potent cardiotonic effects in pentobarbital-induced heart failure but only slight effect on the normal heart. 280 μg of oxyfedrine corresponded with 64 μg of ouabain in this respect. Increasing doses of ouabain resulted in ventricular extrasystoles and fibrillation at 76 and 125 μg respectively on the average, but no arrhythmia was observed even with 5 mg of oxyfedrine. Cardiotonic effect of oxyfedrine was prevented by pretreatment of the heart with propranolol but was intact in reserpinized HLP.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00498787
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Metabolism of oxyfedrine (1972)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 275 (1972), S. 323-337 
    Details
    ISSN: 1432-1912
    Keywords: Oxyfedrine ; Biliary Excretion ; Norephedrine ; Catecholamine Release
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Pharmacokinetic studies with orally administered 14C-oxyfedrine were carried out in rats and also in men. 1. In the rat tissue concentrations of oxyfedrine (determined by UV absorption) and 14C-radioactivity reached a maximum within 15 min. Recovery of oxyfedrine equaled that of 14C-activity (14C-oxyfedrine + 14C-labelled metabolites) in the heart and lung tissues, but differed somewhat in the liver and kidney extracts. 2. In experiments with bile fistula rats, 3 metabolites were recovered in the bile: a main metabolite, as an unlabeled, ninhydrin-positive substance (M1) besides two 14C-labeled minor metabolites*. 3. Approximately 40 to 50% of the oxyfedrine applied appeared in the urine as metabolites of oxyfedrine, mainly norephedrine, in rats and men. 4. The pharmacological significance of these findings is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00500060
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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