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  • 1
    ISSN: 1434-0879
    Keywords: Nude mice ; Human prostatic tumor models ; PC-82 ; PC-EW ; Prostatic acid phosphatase
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The correlation between tumor volume of untreated tumor-bearing nude mice and serum concentration of prostatic acid phosphatase (PAP/RIA) was studied in the hormone-dependent serially transplantable human prostatic tumor models PC-82 and PC-EW. The normal serum level of PAP in control male nude mice without tumor was found to be 0.9±0.3 ng/ml. Elevated PAP serum concentrations were never found in animals without tumor (a highly specific diagnostic technique). A close correlation was observed between the concentration of PAP in the serum (range 0.3 to 154 ng/ml) and the tumor volume (range 10.0 to 6, 530 mm3) of 104 untreated mice bearing a PC-82 or PC-EW human prostatic tumor. This correlation was comparable in both tumor lines (p〈0.001). The positive effect of endocrine manipulation which resulted in tumor diameter decrease or growth arrest with regressive histogical patterns, showed the normal PAP serum level, too. After successful treatment PAP was found to be normal, independent from the residual tumor mass. By contrast, in the event of only retarded tumor growth, the PAP level still correlated with the tumor burden.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Langenbeck's archives of surgery 345 (1977), S. 563-564 
    ISSN: 1435-2451
    Keywords: Vegetative trauma by anesthesiologic drugs ; central inhibiting ; peripherical ganglioplegic ; Abdominopelvic voiding reflux ; operative inhibition ; Vegetatives Trauma anaesthesiologischer Pharmaka ; zentral inhibitiv ; peripher gangliophlegisch ; operative Inhibition des abdom. pelv. Mikt. Reflexes ; dekomp. vorbestehende Obstruktion und Neuropathie ; infranukleäre Neuronläsion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: ZusammenfaBung Die MiktionBtörung nach allgemeinchirurgischen Operationen hat drei Ursachen. Sie existieren einzeln oder kombiniert. Erste Ursache ist ein Trauma anaesthesiologischer Pharmaka. Sie haben einen zentralen Angriffspunkt im Stammhirn und einen peripheren in den parasympathischen und sympathischen Ganglien der Harnblase. Zweite Ursache ist ein operatives Trauma des abdomino-pelvischen Initialreflexes der Miktion. Beide Traumata, das vegative und das mechanische dekompensieren eine vorbestehende neuropathische oder obstruktive Minderung der Harnblase. Beide Traumata werden prolongiert von abdominaler, pulmonaler und zerebraler Insuffizienz. Dritte Ursache ist eine direkte Verletzung des sacralen Plexus pelvicus. - Die postoperative MiktionBtörung betrifft ca. 25 % aller Operierten. Kinder sind spezifisch selten beteiligt. Operationen an der unteren Körperhälfte verursachen die MiktionBtörung viel häufiger als Operationen an der oberen Körperhälfte oder an Extremitäten. Die Therapie besteht in sinnvoller, liberaler und differenzierter Anwendung des Katheters, weiter in parasympathicomimetischer und sympathicolytischer Medikation, in den obstruktiv oder neuropathisch dekompensierten Fällen in transurethraler operativer Korrektur des BlasenauslaBes.
    Notes: Summary Impaired micturition after general surgical operations can be due to three causes , which occur individually or in combination. The first comprises side effects of anesthetics upon the autonomic nervous system. Inhibition of the abdominopelvic reflex, initiating micturition, due to the operative trauma represents the scond cause. Both the vegetative and the mechanical traumas, lead to decompensation of the urinary bladder, whose function is impaired by neuropathic factors and outflow obstruction. Pulmonary, cerebral, and abdominal insufficiency prolong the effects of both traumas. The third cause is direct operative injury of the sacroplexus pelvus. - Approximately 25 % of all patients undergoing surgery will shown voiding disturbances in the postoperative period. The treatment consists sympatholytic therapy. In cases of neuropathic and obstructed bladders, the treatment of choice is transurethral correction of the bladder outlet.
    Type of Medium: Electronic Resource
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