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  • 1
    Electronic Resource
    Electronic Resource
    Parathyroid hormone concentration gradients across the human bone marrow (1983)
    Springer
    Calcified tissue international 35 (1983), S. 591-595 
    Details
    ISSN: 1432-0827
    Keywords: Parathyroid hormone ; Bone marrow blood ; Antecubital vein blood ; Arterio-venous differences
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Summary Parathyroid hormone (PTH) concentrations were compared in blood drawn from the bone marrow and antecubital vein of patients undergoing marrow biopsy for suspected hematological neoplasia. Radioimmunological analysis revealed that the bone marrow blood had a higher PTH content than blood from the peripheral circulation. Thyroid hormone-binding globulin was not distributed asymmetrically, showing that the gradient is PTH specific. The intact PTH content of marrow blood was 65% greater than that in the venous system, whereas carboxyl regional PTH levels showed a 34% gradient in favor of the marrow. Although the majority of patients were found to have hematological malignancies, there was no discernable influence of tumor on the PTH gradients. The physiological implications and possible origins of the asymmetrical PTH distribution are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02405099
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Osteoporosis: A bone turnover defect resulting from an elevated parathyroid hormone concentration within the bone-marrow cavity? (1984)
    Springer
    Journal of molecular medicine 62 (1984), S. 129-132 
    Details
    ISSN: 1432-1440
    Keywords: Bone-marrow blood ; Parathyroid hormone ; Osteoporosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Recently the bone-marrow cavity blood concentration of parathyroid hormone (PTH) has been shown to exceed that of the peripheral blood. As PTH is a primary modulator of bone cell activity, altered levels of the hormone in the bone-marrow blood may play a significant role in the aetiology of bone disease. We therefore measured PTH concentrations in marrow cavity and venous blood of 9 osteoporotic and 14 control subjects using sequence specific radioimmunoassays for intact and mid-carboxyl (Mid-C) regional human PTH (hPTH). Intact and Mid-C PTH levels were identical in the peripheral blood of control and osteoporotic subjects. Furthermore, bone-marrow cavity blood concentrations of Mid-C PTH, whilst universally higher than those found in peripheral blood, were also comparable in the osteoporotic and control subjects. The sole difference in the PTH composition of bone-marrow cavity blood from osteoporotic subjects was an increased concentration of intact PTH. The origins and consequences of elevated levels of intact PTH within the marrow cavity blood of osteoporotic subjects are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01738703
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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