ISSN:
1432-1459
Keywords:
Leber's optic neuropathy
;
Magnetic resonance imaging
;
Parinaud's syndrome
;
Oculopalatal myoclonus
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Six months after the onset of visual loss a 23-year-old male patient with Leber's optic neuropathy associated with a mitochondrial DNA mutation developed brain stem involvement with Parinaud's syndrome and oculopalatal myoclonus. Magnetic resonance imaging (MRI) revealed a high signal area in the brain stem, corresponding to a hypodense area in the CT scan that did not show contrast enhancement. Distinct diminution but not complete remission of the MRI findings was found in the 5-year follow-up, which was not accompanied by clinical improvement. Although the MRI findings were compatible with a demyelinating lesion, neither extensive evoked potential studies nor spinal fluid examination supported this.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00818714
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