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Midbrain dopaminergic neurons are protected from radical induced damage by GDF-5 application (1999)

Lingor, P. ; Unsicker, K. ; Krieglstein, K.

Springer

Journal of neural transmission 106 (1999), S. 139-144

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ISSN: 1435-1463

Keywords: Keywords: Dopaminergic neurons ; neurotrophic factors ; Fe2+ ; NO ; Parkinson's disease (PD).

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Summary. Embryonic day 14 rat midbrain cultures were kept for 7 days in vitro and then intoxicated with radical donors iron and sodium-nitroprusside for 24 h. Tyrosine-hydroxylase positive neurons in cultures which were additionally treated with growth/differentiation factor-5 (GDF-5) survived to a significantly higher percentage as compared to sister cultures without factor supplementation. Since the degeneration of TH positive cells is a key feature in Parkinson's disease, GDF-5 might be a putative therapeutical agent for this disorder.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/s007020050146

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