ISSN:
1435-1463
Keywords:
Keywords: Dopaminergic neurons
;
neurotrophic factors
;
Fe2+
;
NO
;
Parkinson's disease (PD).
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary. Embryonic day 14 rat midbrain cultures were kept for 7 days in vitro and then intoxicated with radical donors iron and sodium-nitroprusside for 24 h. Tyrosine-hydroxylase positive neurons in cultures which were additionally treated with growth/differentiation factor-5 (GDF-5) survived to a significantly higher percentage as compared to sister cultures without factor supplementation. Since the degeneration of TH positive cells is a key feature in Parkinson's disease, GDF-5 might be a putative therapeutical agent for this disorder.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/s007020050146
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