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  • 1
    Electronic Resource
    Electronic Resource
    Intraperitoneal hypercoagulation and hypofibrinolysis is present in childhood peritonitis (1999)
    Springer
    Pediatric nephrology 13 (1999), S. 284-287 
    Details
    ISSN: 1432-198X
    Keywords: Key words Fibrinolysis ; Peritonitis ; Peritoneal dialysis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  An increased rate of obstruction of peritoneal dialysis catheters is observed during peritonitis. Hypercoagulation and hypofibrinolysis may explain this increased occurrence. We studied plasminogen activator inhibitor type 1 antigen (PAI-1), tissue-type plasminogen activator antigen (t-PA), D-dimer (DD), plasmin-α2-antiplasmin complexes (PAP), and thrombin-antithrombin III complexes (TAT) in 7 children with peritonitis (group A) and 12 children during stable peritoneal dialysis (group B). Albumin, β2-microglobulin, IgG, and α2-macroglobulin were measured for baseline transperitoneal protein transport. After a dwell of 6 h with 1.36% Dianeal, dialysate and serum samples were collected. Dialysate to plasma ratios of all proteins were calculated. During peritonitis (group A) TAT was higher: 34.7 versus 22.0 (P=0.01). PAI-1 was increased in group A: 76.5 versus 22.9 (P=0.004). PAP was decreased during peritonitis (group A): 24.9 versus 39.3 (P=0.01). In group A, DD were decreased. 10.8 versus 26.7 (P=0.002). t-PA was similar in both groups (23.7 in group A vs. 27.7 in group B; P=0.26). In both groups TAT, PAI-1, t-PA, PAP, and DD were significantly higher than in baseline transperitoneal transport, suggesting intraperitoneal production. Hypercoagulability and hypofibrinolysis were present during peritonitis compared with the control situation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004670050609
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  • 2
    Electronic Resource
    Electronic Resource
    Clinical experience with icodextrin in children: ultrafiltration profiles and metabolism (2000)
    Springer
    Pediatric nephrology 15 (2000), S. 21-24 
    Details
    ISSN: 1432-198X
    Keywords: Key words Icodextrin ; Peritoneal dialysis ; Ultrafiltration ; Metabolism ; Dialysis adequacy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Icodextrin use in adults provides sustained ultrafiltration (UF) in long-term dwells. No information is available on UF and metabolism in children. In 11 children, a volume of 1,049±138 ml/m2 of the study fluid (1.36% glucose, 7.5% icodextrin, 3.86% glucose) was administered for 12 h. Net UF with icodextrin (339±147 ml/1.73 m2) did not differ from UF with 3.86% glucose (450±306 ml/1.73 m2, P=0.53) and was higher than UF with 1.36% glucose (–87±239 ml/1.73 m2, P=0.003). Icodextrin added 0.52±0.07 to the weekly Kt/V. Over 6 weeks, icodextrin was used for 12-h daytime dwell. Total icodextrin reached a steady-state level of 2.91±1.22 g/l at 2 weeks. The main icodextrin metabolites were maltose, maltotriose, and maltotetraose. After 2 weeks, steady state levels were 2.02±0.66 mmol/l, 1.46±0.35 mmol/l, and 0.45±0.12 mmol/l. No icodextrin or metabolites were detectable 4 weeks after the study. We conclude that 7.5% icodextrin is capable of maintaining UF during 12-h dwell in children and is comparable to UF obtained with 3.86% glucose. Steady-state levels of icodextrin and metabolites were reached at 2 weeks and disappeared after the study.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004670000406
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    Paper (German National Licenses)
    Fulltext
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