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  • 1
    Electronic Resource
    Electronic Resource
    Evidence for glycoprotein components of the hepatocellular bile acid transporter
    Amsterdam : Elsevier
    Biochimica et Biophysica Acta (BBA)/Biomembranes 903 (1987), S. 510-518 
    Details
    ISSN: 0005-2736
    Keywords: (Rat liver) ; Bile acid transporter ; Cholate ; Glycoprotein ; Lectin affinity chromatography ; Phalloidin
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Medicine , Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0005-2736(87)90058-7
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Cyclosporin A protects liver cells against phalloidin - Potent inhibition of the inward transport of cholate and phallotoxins
    Amsterdam : Elsevier
    Biochimica et Biophysica Acta (BBA)/Molecular Cell Research 805 (1984), S. 174-180 
    Details
    ISSN: 0167-4889
    Keywords: (Liver cell) ; Cholate transport ; Cyclosporin A ; Phalloidin ; Phallotoxin
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Medicine , Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0167-4889(84)90165-4
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Decreased sensitivity of isolated hepatocytes from baby rats, from regenerating and from poisoned livers to phalloidin (1979)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 306 (1979), S. 295-300 
    Details
    ISSN: 1432-1912
    Keywords: Phalloidin ; Baby rats ; Regenerating liver ; Carbon tetrachloride ; Actin ; Bile acids
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Isolated hepatocytes, prepared from 5 day old rats, from regenerating livers or from livers after poisoning with carbon tetrachloride, are less sensitive to phalloidin in vitro than hepatocytes from untreated adult controls. The time course of the reduced susceptibility to phalloidin was compared with the ability of hepatocytes to take up bile acids under various conditions. SDS-electrophoresis of cell lysates gave no evidence for decreased levels of actin in cells with reduced sensitivity to phalloidin. In contrast, there was a good relationship between the active uptake of bile acids and the sensitivity of hepatocytes to phalloidin. The decreased response of hepatocytes from baby rats, from regenerating livers or from poisoned livers to phalloidin is more probably related to differences in phalloidin uptake than to a reduced endowment with microfilamentous structures.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00507117
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Is ligandin relevant for the uptake and storage of phallotoxins in liver cell? (1981)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 317 (1981), S. 364-367 
    Details
    ISSN: 1432-1912
    Keywords: Isolated hepatocytes ; Phalloidin ; Ligandin ; Protein binding
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary To exclude an involvement of ligandin in the uptake and storage of phalloidin in hepatocytes equilibriumdialysis studies were made with phalloidin, cholic acid and bromosulfophthalein (BSP). Binding studies with isolated ligandin indicated that the affinity of ligandin for phalloidin is low (K D=0.8×10−3 M). Phalloidin neither displaced BSP (K D=1.3×10−7M) or cholic acid (K D=7.6×10−5 M) from ligandin, when preloaded with these substrates. Hepatocytes prepared from rats after daily treatment with phenobarbital during 5 days contained 3–4-fold concentrations of ligandin and bound greater amounts of BSP than controls. Nevertheless the velocity of the uptake both of [3H]-demethylphalloin ([3H]-DMP) and of [35S]-BSP was not augmented. Also the sensitivity of liver cells to phalloidin was not drastically modified after induction with phenobarbital and agrees with earlier findings in vivo. We conclude that ligandin plays a negligible role in the uptake and a minor role in the storage of phallotoxins in liver cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00501320
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Isolation of hepatocytes from newborn rats (1980)
    Springer
    Archives of toxicology 44 (1980), S. 99-105 
    Details
    ISSN: 1432-0738
    Keywords: Newborn rats ; Isolated hepatocytes ; Phalloidin ; 3H-Demethylphalloin ; Bile acids
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A method is described for the preparation of isolated hepatocytes from 5 day old rats, based on the procedure of Berry and Friend (1969). In contrast to the original procedure the liver of newborn rats was perfused in the reverse direction from the vena cava caudalis (pars thoracalis) to the vena portae. The cells obtained by the above method are morphologically intact as shown by electron micrographs and by phase contrast microscopy. About 85% of the isolated cells excluded trypan blue. Neonatal liver cell preparations were used for dose response studies with phallotoxins and further experimental applications in the field of phalloidin tolerance of newborns are described.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00303186
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  • 6
    Electronic Resource
    Electronic Resource
    Uptake of 3H-demethylphalloin by isolated hepatocytes in the presence of various concentrations of phalloin or phalloidin (1980)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 311 (1980), S. 91-94 
    Details
    ISSN: 1432-1912
    Keywords: Phalloidin ; Phalloin ; Demethylphalloin ; Isolated hepatocytes ; Uptake kinetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The uptake of trace amounts of 3H-demethylphalloin (3H-DMP) by isolated hepatocytes was studied in the presence of various concentrations of unlabeled demethylphalloin (DMP), of phalloin and of phalloidin. The addition of phalloidin (or phalloin) reduces the uptake of 3H-DMP more than the addition of the equivalent concentration of DMP. The error caused by dilution of 3H-DMP with phalloin or phalloidin is not constant and depends on the concentration of the unlabeled compound. The relative differences between the uptake of 3H-DMP in the presence of demethylphalloin and in the presence of either phalloin or phalloidin cannot be explained by a competitive model. Some consequences for the use of 3H-DMP in toxicokinetic experiments are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00500308
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    Paper (German National Licenses)
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