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  • 1
    Electronic Resource
    Electronic Resource
    Pharmacokinetic studies of high-dose metoclopramide with and without forced diuresis (1985)
    Springer
    Journal of molecular medicine 63 (1985), S. 572-574 
    Details
    ISSN: 1432-1440
    Keywords: Metoclopramide ; High dose Metoclopramide ; Pharmacokinetics ; Antiemetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The pharmacokinetics of high-dose metoclopramide (10 mg/kg body wt. in five infusions of 2 mg/kg body wt. each) was studied in 11 patients (5 females, 6 males) in two groups: group A with and group B (consisting of five patients) without forced diuresis. When the drug was infused, forced diuresis had no influence on the pharmacokinetics of metoclopramide (serum level after the 1st infusion was 851±361 ng/ml in group A versus 840±348 ng/ml in group B; after the 5th infusion it was 2,005±588 ng/ml in group A versus 2,463±1,350 ng/ml in group B). There were significant differences in the 24-h serum levels (582±308 ng/ml in group A versus 379±170 ng/ml in group B;P〈0.05) and in the elimination half life (8.5±2.6 h in group A versus 6.1±1.1 h in group B;P〈0.05). The results demonstrate that the dosage regimen originally suggested by Gralla for cytostatic drugs, with forced diuresis for high-dose metoclopramide therapy, may also be applied, with no dosage reduction, with to other cytostatic drugs which do not require forced diuresis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01733203
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Non-invasive quantification of organ damage (1995)
    Springer
    Comparative clinical pathology 5 (1995), S. 120-124 
    Details
    ISSN: 1433-2981
    Keywords: Creatine kinase ; Enzymes ; Imaging ; Organ damage ; Pharmacokinetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Quantitative evaluation of organ damage can be achieved by non-invasive, direct or indirect methods. Direct methods include echography, tomography, scintigraphy and magnetic resonance. The accuracy of these imaging techniques has been demonstrated in human medicine. Most of them have not been validated in animals, however, and their use is limited by cost. Indirect methods are based on determination of the total release of intracellular markers (mainly enzymes) into body fluids. Quantification of organ damage depends on extracellular disposition of the marker. Thus, in the kidney, the marker is directly and totally leaked into the urine and is voided at each micturition. The amount of marker eliminated in this way allows easy quantification of organ damage occurring during the period preceding the micturition. Muscle markers with molecular weights exceeding 50 kDa reach the blood via the lymph. This results in (a) partial inactivation, (b) delay between cell damage and increased plasma concentration and (c) accumulation in the plasma as long as delivery into the plasma exceeds clearance. In such cases, quantitative evaluation requires pharmacokinetic tools and calculation of the area under the curve (concentration vs time) and of the plasma clearance. Comparison of the intensity and chronology of markers located in different cell compartments may contribute to the understanding of pathophysiological events.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00638930
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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