ISSN:
1432-1440
Keywords:
Metoclopramide
;
High dose Metoclopramide
;
Pharmacokinetics
;
Antiemetics
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary The pharmacokinetics of high-dose metoclopramide (10 mg/kg body wt. in five infusions of 2 mg/kg body wt. each) was studied in 11 patients (5 females, 6 males) in two groups: group A with and group B (consisting of five patients) without forced diuresis. When the drug was infused, forced diuresis had no influence on the pharmacokinetics of metoclopramide (serum level after the 1st infusion was 851±361 ng/ml in group A versus 840±348 ng/ml in group B; after the 5th infusion it was 2,005±588 ng/ml in group A versus 2,463±1,350 ng/ml in group B). There were significant differences in the 24-h serum levels (582±308 ng/ml in group A versus 379±170 ng/ml in group B;P〈0.05) and in the elimination half life (8.5±2.6 h in group A versus 6.1±1.1 h in group B;P〈0.05). The results demonstrate that the dosage regimen originally suggested by Gralla for cytostatic drugs, with forced diuresis for high-dose metoclopramide therapy, may also be applied, with no dosage reduction, with to other cytostatic drugs which do not require forced diuresis.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01733203
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