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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Journal of cancer research and clinical oncology 116 (1990), S. 439-442 
    ISSN: 1432-1335
    Keywords: D-19466 ; New drug ; Platinum complex ; Antitumor activity ; Pre-clinical
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary D-19466, a new platinum complex, was characterized. It showed no nephrotoxic side-effects as determined by the measurement of blood urea. It was cytotoxic in vitro for tumor cells in concentrations comparable to or lower than cytotoxic concentrations of cisplatin. It had excellent anticancer activity in vivo against a number of murine experimental tumors, including a cisplatin-resistant P388 line. Clinical evaluation of this compound has therefore been initiated.
    Type of Medium: Electronic Resource
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