Library

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Electronic Resource
    Electronic Resource
    Metabolic oxidation of methaqualone in extensive and poor metabolisers of debrisoquine (1982)
    Springer
    European journal of clinical pharmacology 23 (1982), S. 147-150 
    Details
    ISSN: 1432-1041
    Keywords: methaqualone ; debrisoquine ; pharmacogenetics ; metabolism ; oxidation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The metabolism of methaqualone to the glucuronides of 5 C-monohydroxy metabolites and to the N-oxide has been studied in 2 groups of healthy young adults phenotyped as extensive and poor metabolisers of debrisoquine. No significant interphenotype differences were observed with respect to the excretion of any of the 6 metabolites. It is probable that the genetic regulation of the pathways leading to these metabolites is at a locus other than that which is responsible for the regulation of the oxidation of debrisoquine, guanoxan, phenacetin, phenytoin and sparteine.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00545969
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Inter- and intra-individual variation in the metabolism of methaqualone in man after a single oral dose (1978)
    Springer
    European journal of clinical pharmacology 13 (1978), S. 291-297 
    Details
    ISSN: 1432-1041
    Keywords: Drug metabolism ; methaqualone ; methaqualone metabolites ; interindividual variation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The urinary excretion of fiveC-monohydroxy metabolites and theN-oxide metabolite of methaqualone in the 24h period immediately after oral dosing with 250 mg methaqualone (Melsed) has been measured in nineteen healthy adults (13 male, 6 female) to assess interindividual variations and in five adults (3 male, 2 female) on five separate occasions to assess intraindividual variations. The overall importance of the six metabolites was 4′-hydroxy $$ 〉 〉 $$ N-oxide $$ 〉 〉 $$ 2′-hydroxymethyl 〉 3′-hydroxy 〉 6-hydroxy = 2-hydroxymethyl. Variations in this order both within the 24h period and within each of the three eight-hour periods constituting the 24 hours were minor and variations in the absolute amount of each metabolite excreted ranged from two to three-fold. Intraindividual variations were generally smaller than interindividual variations and for each individual the pattern of metabolism was similar on the five occasions. There is evidence that theC-oxidation of methaqualone may be more sensitive to cyclical variations in hormone levels than isN-oxidation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00716365
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    The preparation of high-viscosity, partially hydrolyzed polymethacrylamides (1983)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Applied Polymer Science 28 (1983), S. 3607-3610 
    Details
    ISSN: 0021-8995
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Due to the high chain transfer to monomer, the homopolymerization of methacrylamide yields polymers of extremely low molecular weight. On partial alkaline hydrolysis, the viscosities of these polymers in aqueous solution are much inferior to those of partially hydrolyzed polyacrylamide (HPAM). However, polymethacrylamides prepared by room temperature, persulfate-initiated polymerization in the presence of small amounts of N,N′-methylenebisacrylamide demonstrate posthydrolysis reduced viscosities in 0.01% NaCl comparable to typical commercial HPAM materials.
    Additional Material: 3 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/app.1983.070281201
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 4
    Electronic Resource
    Electronic Resource
    Partially imidized, water-soluble polymeric amides. I. Partially imidized polyacrylamide and polymethacrylamide (1983)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Applied Polymer Science 28 (1983), S. 3611-3617 
    Details
    ISSN: 0021-8995
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Five to six million molecular weight polyacrylamide and polymethacrylamides of comparable post-alkaline hydrolysis viscosities were imidized by dissolution and heating in 6N HCl. After alkaline hydrolysis, the imidized polymers demonstrated significantly better retention of viscosity to 2% NaCl than did similar partially hydrolyzed polymers. Viscosities in 0.01% NaCl and resistance to shear were not markedly affected by this modification. It is assumed that this improved performance in brine is the result of chain stiffening due to intrachain imide rings.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/app.1983.070281202
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 5
    Electronic Resource
    Electronic Resource
    Poly-1-hexene, synthesis and solubility in dense carbon dioxide (1986)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Applied Polymer Science 32 (1986), S. 3775-3781 
    Details
    ISSN: 0021-8995
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Several poly-1-hexene samples were prepared using different Ziegler-Natta catalysts, and their solubilities in dense carbon dioxide (CO2) were studied. Despite the varied molecular weight distributions (MWD) in the polymers, a surprising correlation was found between intrinsic viscosity and dense CO2 solubility. Due to the ability of dense CO2 to extract low-molecular weight fractions preferentially, it is recommended that narrow MWD polymers be used, as far as possible, for dense CO2 solubility determinations.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/app.1986.070320232
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 6
    Electronic Resource
    Electronic Resource
    Synthesis, characterization, and mechanical properties of PMMA/poly(aromatic/aliphatic siloxane) semi-interpenetrating polymer networks (1996)
    Bognor Regis [u.a.] : Wiley-Blackwell
    Journal of Polymer Science Part A: Polymer Chemistry 34 (1996), S. 1025-1037 
    Details
    ISSN: 0887-624X
    Keywords: polymer networks ; crosslinked polymers ; tensile properties ; Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Semi-interpenetrating polymer networks (IPNs) composed of poly(methyl methacrylate) (PMMA) and aromatic/aliphatic siloxanes have been made via sequential and simultaneous polymerizations. As the percentage of aliphatic siloxane increases, flexibility and, in general, toughness of the IPNs increases and clarity is reduced. This loss in clarity is due to the mismatch of refractive indices (1.49 form PMMA vs. 1.43 for aliphatic siloxane). PMMA is quite transparent. On the other hand, in making aromatic siloxane/PMMA IPNs clarity is retained as aromatic siloxane is increased due to better matching refractive index (1.49 for PMMA and -1.49 for poly(diphenyl siloxane)). Gel permeation chromatography (GPC) indicates slightly crosslinked IPNs with the THF soluble portions having number-average molecular weight, M¯n, of 105-106. NMRs of IPNs essentially show peaks for the components, PMMA and the siloxane, which make up the respective IPNs. 29Si-NMRs indicate cross-linking and grafting. Mechanical properties show increased toughness of IPNs versus PMMA as percentage of siloxane and crosslinker increases, but with a corresponding loss in tensile strength. © 1996 John Wiley & Sons, Inc.
    Additional Material: 13 Ill.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
  • 7
    Electronic Resource
    Electronic Resource
    Kinetics of 1-hexene polymerization (1986)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Applied Polymer Science 32 (1986), S. 5373-5383 
    Details
    ISSN: 0021-8995
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Kinetics of 1-hexene polymerization was studied by following the amount of unreacted monomer using gas chromatography. The Ziegler-Natta catalyst system used was comprised of TiCl4-AlEt3 with Al: Ti ratio of 0.85. The sampling and monomer analysis techniques developed can be applied to study the kinetics of higher α-olefins polymerizations, in general. Also, with minor modifications in this technique, a precise profile of molecular weight can be obtained during polymerization.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/app.1986.070320611
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...