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  • 1
    Electronic Resource
    Electronic Resource
    Responses of prolactin and growth hormone to L-tryptophan infusion: Effects in normal subjects and schizophrenic patients receiving neuroleptics (1985)
    Springer
    Psychopharmacology 86 (1985), S. 164-169 
    Details
    ISSN: 1432-2072
    Keywords: l-Tryptophan ; Growth hormone ; Prolactin ; Neuroleptics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Intravenous infusion of l-tryptophan (LTP) in 18 normal subjects produced a significant increase in plasma prolactin (PRL), growth hormone (GH), and self-ratings of drowsiness. There was no correlation between the PRL and GH responses, or between the hormonal responses and drowsiness. Saline infusion did not result in endocrine or psychological changes. The effect of LTP on both PRL and GH was dose-related in that LTP 7.5 g produced greater endocrine responses than 5.0 g. It was not significantly decreased by cyproheptadine, a 5-HT receptor antagonist. Schizophrenic patients receiving neuroleptics had increased PRL response to LTP, possibly because of the drug-induced disinhibition of PRL release. Their GH response to LTP was markedly decreased. The mechanism of this effect requires further investigation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00431703
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  • 2
    Electronic Resource
    Electronic Resource
    Clomipramine enhances prolactin and growth hormone responses to l-tryptophan (1986)
    Springer
    Psychopharmacology 89 (1986), S. 131-133 
    Details
    ISSN: 1432-2072
    Keywords: l-Tryptophan ; Clomipramine ; Prolactin ; Growth hormone
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The effects of the 5-hydroxytryptamine (5-HT) uptake inhibitor clomipramine on the prolactin (PRL) and growth hormone (GH) responses to l-tryptophan (LTP) were assessed in six normal subjects. Oral administration of 20 mg clomipramine 2 h prior to LTP infusion (50 mg/kg) significantly enhanced both endocrine responses, suggesting that the increases in plasma PRL and GH produced by LTP are mediated by 5-HT pathways. These findings, taken together with previous observations that 5-HT2 receptor antagonists do not attenuate the PRL response to LTP, suggest that the 5-HT-induced release of PRL in man may be mediated by 5-HT1 receptors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00175205
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  • 3
    Electronic Resource
    Electronic Resource
    The effects of chronic ritanserin treatment on sleep and the neuroendocrine response to l-tryptophan (1987)
    Springer
    Psychopharmacology 93 (1987), S. 416-420 
    Details
    ISSN: 1432-2072
    Keywords: 5-HT2 antagonist ; Sleep ; Platelet ; Tryptophan ; Prolactin ; Growth hormone ; 5-HT-receptors
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A previous study has shown that acute administration of the 5-HT2 receptor antagonist ritanserin doubles Slow Wave Sleep (SWS) and increases the prolactin (PRL) response to l-tryptophan (LTP). The present study investigated the effect of repeated ritanserin treatment on sleep, neuroendocrine response to LTP and 5-HT2 platelet receptor binding. After 2 weeks, ritanserin administration SWS was persistently increased but the PRL response to LTP was unchanged. Platelet 5-HT receptor binding was undetectable at the end of ritanserin treatment but recovered 2 weeks after drug withdrawal. The results suggest that ritanserin causes a sustained effect on the 5-HT mechanisms mediating SWS and on platelet 5-HT2 receptors. However, adaptation occurs to its effect on 5-HT-mediated neuroendocrine responses.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00207228
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  • 4
    Electronic Resource
    Electronic Resource
    The effect of lithium on 5-HT-mediated neuroendocrine responses and platelet 5-HT receptors (1986)
    Springer
    Psychopharmacology 90 (1986), S. 398-402 
    Details
    ISSN: 1432-2072
    Keywords: Lithium ; Tryptophan ; Prolactin ; Growth hormone ; 5-HT receptors ; Imipramine binding
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The effect of lithium on serotonin (5-HT)-mediated responses in the brain was assessed by measuring changes in the prolactin (PRL) and growth hormone (GH) responses to l-tryptophan (LTP) in eight normal subjects. On the 4th day of lithium treatment the PRL responses were significantly enhanced, and this enhancement was still apparent after 20 days' treatment. In contrast, GH responses to LTP were not altered. Lithium had no effect on platelet 5-HT content, platelet imipramine binding and platelet 5-HT receptor binding. The ability of lithium to enhance some aspects of brain 5-HT function may be important in its mode of action in manic-depressive illness and may be particularly relevant to its potentiation of the antidepressant effect of tricyclic antidepressants.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00179198
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  • 5
    Electronic Resource
    Electronic Resource
    Lithium increases 5-HT-mediated prolactin release (1989)
    Springer
    Psychopharmacology 99 (1989), S. 276-281 
    Details
    ISSN: 1432-2072
    Keywords: Lithium ; 5-HT ; Clomipramine ; Haloperidol ; Prolactin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The effects of short-term (3–4 days) lithium treatment on the prolactin responses to intravenous clomipramine (0.1 mg/kg), metoclopramide (5 μg/kg) and haloperidol (2.5–5 μg/kg) were assessed in male volunteers. Prolactin responses to clomipramine were significantly enhanced by lithium while those following administration of haloperidol and metoclopramide were not significantly altered. Lithium did not change the cortisol response to clomipramine. The results suggest that lithium may selectively enhance 5-HT mediated prolactin release. These data are consistent with the hypothesis that synergistic effects of lithium and clomipramine on brain 5-HT function may be involved in their therapeutic effect in resistant depression.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00442822
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  • 6
    Electronic Resource
    Electronic Resource
    Ritanserin attenuates anorectic, endocrine and thermic responses tod-fenfluramine in human volunteers (1993)
    Springer
    Psychopharmacology 112 (1993), S. 461-466 
    Details
    ISSN: 1432-2072
    Keywords: d-Fenfluramine ; Ritanserin ; Food intake ; Prolactin ; Body temperature ; Human volunteers
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract This study investigated the role of the 5-HT2/1C receptor antagonist ritanserin ond-fenfluramine (d-FF) induced changes in food intake, prolactin (PRL) secretion and oral temperature in 12 healthy male volunteers. The study was double blind and placebo controlled. Food intake was measured using an automated food dispenser.d-FF (30 mg) significantly reduced fat intake. While ritanserin (5 mg) had no effect when given alone it abolished thed-FF induced reduction in fat intake. In addition, ritanserin abolished thed-FF induced rise in PRL and oral temperature. The results suggest that 5-HT2 or 5-HT1C receptors mediate the effects ofd-fenfluramine on appetite, prolactin secretion and temperature in humans.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02244895
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  • 7
    Electronic Resource
    Electronic Resource
    Neuroendocrine effects of sumatriptan (1994)
    Springer
    Psychopharmacology 113 (1994), S. 561-564 
    Details
    ISSN: 1432-2072
    Keywords: 5-HT receptor ; Sumatriptan ; Prolactin ; Cortisol ; Growth hormone
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The neuroendocrine effects of the 5-HT receptor agonist, sumatriptan (6 mg subcutaneously), were studied in 11 healthy male subjects using a placebo-controlled, cross-over design. Compared to placebo, sumatriptan significantly lowered levels of plasma prolactin but increased those of plasma growth hormone. There was no effect on plasma cortisol concentrations. The neuroendocrine effects of sumatriptan differ from those of previously described 5-HT-receptor agonists, and may be a consequence of selective activation of 5-HT1D or 5-HT1B receptors. However, the present data cannot exclude the possibility that the neuroendocrine changes reflect non-specific stress responses or changes in pituitary blood flow.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02245240
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  • 8
    Electronic Resource
    Electronic Resource
    Pindolol decreases prolactin and growth hormone responses to intravenousL-tryptophan (1991)
    Springer
    Psychopharmacology 103 (1991), S. 140-142 
    Details
    ISSN: 1432-2072
    Keywords: 5-HT1A receptor ; Growth hormone ; Prolactin ; Pindolol ; Tryptophan
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The effects of pindolol on the prolactin (PRL) and growth hormone (GH) responses to intravenous tryptophan (LTP) were studied in eight healthy male volunteers. Pindolol pretreatment (40 mg over 48 h) markedly attenuated the GH response to LTP and modestly, but significantly, reduced the LTP-induced increase in plasma PRL. The disposition of LTP following infusion was not altered by pindolol. While the data are consistent with 5-HT1A receptor mediation of PRL and GH responses to LTP, the intrinsic sympathomimetic actions of pindolol might also be involved in the attenuation of the endocrine responses to LTP.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02244090
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  • 9
    Electronic Resource
    Electronic Resource
    Does metergoline selectively attenuate 5-HT mediated prolactin release? (1991)
    Springer
    Psychopharmacology 105 (1991), S. 129-131 
    Details
    ISSN: 1432-2072
    Keywords: Metergoline ; Haloperidol ; d-Fenfluramine ; Prolactin ; Rat ; Human volunteer
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Administration of the non-selective 5-HT receptor antagonist metergoline (0.5 mg/kg) to male rats attenuated the prolactin response to the 5-HT releasing agentd-fenfluramine (7.5 mg/kg) but not to the dopamine receptor antagonist haloperidol (1.5 mg/kg). In contrast, in healthy male volunteers, pretreatment with metergoline (4 mg orally) abolished the prolactin response to intravenous haloperidol (5 µg/kg). The findings suggest that in humans blockade of a prolactin response by a conventional oral dose of metergoline cannot be taken as evidence of involvement of 5-HT-mediated mechanisms.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02316875
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  • 10
    Electronic Resource
    Electronic Resource
    Zolmitriptan-induced growth hormone release in humans: mediation by 5-HT1D receptors? (1999)
    Springer
    Psychopharmacology 145 (1999), S. 223-226 
    Details
    ISSN: 1432-2072
    Keywords: Key words Zolmitriptan ; Triptan ; Growth hormone ; Prolactin ; Ketanserin ; 5-HT1D receptor
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Rationale: Effective neuroendocrine probes of 5-HT1B and 5-HT1D receptor function may facilitate investigation of the role of these receptor subtypes in the pathophysiology of depression and the mode of action of antidepressant medication. Objective: To investigate the neuroendocrine profile of the 5-HT1B/1D receptor agonist, zolmitriptan, in healthy volunteers. Methods: Twelve subjects entered a double-blind, placebo-controlled, cross-over design study of zolmitriptan (5 mg orally). Blood samples were taken at 15-min intervals for assay of prolactin and growth hormone. A further six healthy men were recruited to an equivalent study to examine the effect of ketanserin (a 5-HT receptor antagonist with some preference for 5-HT1D over 5-HT1B receptors) on the growth hormone response to zolmitriptan. Results: Zolmitriptan significantly increased plasma growth hormone but had no effect on plasma prolactin or oral temperature. The increase in growth hormone produced by zolmitriptan was significantly attenuated by ketanserin. Conclusions: We suggest that the ability of triptans such as zolmitriptan, sumatriptan and rizatriptan to increase plasma growth hormone is mediated by their common agonist activity at postsynaptic 5-HT1D receptors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002130051052
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