ISSN:
1434-4726
Keywords:
Prostaglandins
;
Otitis media with effusion
;
Radioimmunoassay
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary The concentrations of prostaglandins (PGs) were measured by a radioimmunoassay in human middle ear effusions (MEEs) obtained from patients with otitis media with effusions. Each sample of MEE was divided into two groups: serous effusions and mucoid ones. The main PG in both the serous and mucoid effusions was TXB2 (375 and 857pg/ml, respectively), followed by PGE2 (173 and 459pg/ml, respectively). Smaller quantities of PGD2 (35 and 64 pg/ml, respectively), PGF2a (139 and 183 pg/ml, respectively), and 6keto PGF1a (129 and 201 pg/ml, respectively) were also found in the MEEs. The amounts of each PG in the mucoid effusions were 2 or 3 times higher than those found in the serous effusions, while protein concentrations and the profile of these PGs in the MEEs were almost the same in the mucoid and serous groups. These results suggest that PGs may play an important role as a mediator of the inflammatory responses in the pathogenesis of MEEs.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00456653
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