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Digitale Medien

Intragastric self-administration of medazepam in rats (1973)

Götestam, K. Gunnar

Springer

Psychopharmacology 28 (1973), S. 87-94

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ISSN: 1432-2072

Schlagwort(e): Psychopharmacology ; Intragastric ; Self-Administration ; Benzodiazepines ; Rat

Quelle: Springer Online Journal Archives 1860-2000

Thema: Medizin

Notizen: Abstract A technique for intragastric self-administration in rats is presented. Intravenous self-administration of morphine was compared with intragstric self-administration during 6 consecutive days. There was no difference between the two routes in the total rate of injections. Medazepam was given for intragastric self-administration at three different doses (2.5, 5.0 and 10.0 mg/kg/injection respectively) and compared with saline. There was an increased response rate at the dose 10 mg/kg/injection. Medazepam placebo solution (solvent alone) was also compared with medazepam 10 mg/kg/injection. Among the seven experimental rats, six responded higher on medazepam than on the solvent.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF00413960

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