ISSN:
0170-2041
Keywords:
Pyrazoles
;
Pyrazolo[5,1-c]-1,2,4-triazoles
;
Chemistry
;
Organic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
Selective Acylations of 3(5)-Alkyl-5(3)-amino-1H-pyrazoles and a New Pyrazolo[5,1-c]-1,2,4-triazole Synthesis(Z)-5-Amino-1-[1-(hydroximino)alkyl]-1H-pyrazoles 3 have been synthesized by acylation of 3(5)-alkyl-5(3)-amino-1H-pyrazoles 1 with nitrile oxides. The tosylation of the hydroxyimino group of 3 to (Z)-5-amino-1-[1-(p-tosyloximino)alkyl]-1H-pyrazoles 4 and the subsequent acetylation of the 5-amino group give (E)- and (Z)-5-acetamido-1-[1-(p-tosyloximino)alkyl]-1H-pyrazoles 5, which undergo cyclization under basic conditions to pyrazolo[5,1-c]-1,2,4-triazoles 6, 7 or 8.
Additional Material:
2 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/jlac.199419941014
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