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  • 1
    ISSN: 1432-0428
    Keywords: RIA HLA typing ; HLA association of Type 1 diabetes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The problem of the HLA association of Type 1 (insulin-dependent) diabetes was re-examined by testing Class II antigenic specificities detectable by radioimmunoassay. Established (DRw53, DQwl, DQw2, DQw3) as well as newly described (DC5, DCalpha3) specificities were typed. The data obtained suggest that the association with DR3 and DR4 is secondary to that with DQ specificities in linkage disequilibrium with DR3 and DR4.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1590-3478
    Keywords: Multiple sclerosis ; T8+cells ; T-cells analysis ; T-cells during clinical phase of MS ; T-lymphocyte subsets ; monoclonal antibodies ; T-cell subsets ; T8+lymphocytes ; blood T-lymphocytes ; lymphocyte subsets
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Sommario Una analisi seriale delle sottopopolazioni T-linfocitarie del sangue periferico è stata eseguita in 280 campioni prelevati in un periodo di 27 mesi da 14 pazienti affetti da Sclerosi Multipla. Una riduzione significativa delle cellule T8+ è stata trovata nel 47,1% (41/87) dei campioni ematici prelevati durante le quattro settimane dopo l'insorgenza della recidiva rispetto al 2,1% (1/47) dei campioni prelevati durante le quattro settimane prima di una recidiva e rispetto al 3,4% (5/146) di quelli prelevati oltre quattro settimane dopo una recidiva. Le variazioni delle sottopopolazioni delle cellule T sembrano correlarsi con l'attività della malattia, ma i valori normali osservati prima delle recidive suggeriscono che la riduzione delle cellule T8+ non può essere usata come un valido predittore delle recidive.
    Notes: Abstract Serial analyses of peripheral blood T-lymphocyte subsets were performed in 280 samples collected over a 27 months period from 14 multiple sclerosis patients. A significant decrease of T8+ cells was found in 47.1% (47/87) of blood samples collected within four weeks of onset of a relapse opposed to 2.1% (1/47) of samples collected during the four weeks before a relapse and to 3.4% (5/146) of those collected over four weeks after a relapse. Changes of T-cells subsets appear to correlate with disease activity, but normal findings observed before relapses suggest that the decrease of T8+ cells cannot be used as valid predictor of relapse.
    Type of Medium: Electronic Resource
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