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  • 1
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Journal of Psychiatric Research 23 (1989), S. 213-220 
    ISSN: 0022-3956
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-0428
    Keywords: RIA HLA typing ; HLA association of Type 1 diabetes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The problem of the HLA association of Type 1 (insulin-dependent) diabetes was re-examined by testing Class II antigenic specificities detectable by radioimmunoassay. Established (DRw53, DQwl, DQw2, DQw3) as well as newly described (DC5, DCalpha3) specificities were typed. The data obtained suggest that the association with DR3 and DR4 is secondary to that with DQ specificities in linkage disequilibrium with DR3 and DR4.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1432-2277
    Keywords: Key words Kidney transplantation immunology ; Kidney transplantation monitoring ; Flow cytometry crossmatch ; Donor-specific antibodies ; Class I histocompatibility antigens immunology
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract This study was designed to investigate the clinical relevance of donor-specific antibodies (DS-Abs) and their influence on graft survival. Among 106 patients who underwent cadaveric kidney donor transplantation and were monitored by flow cytometry crossmatch (FCXM) during the 1st posttransplantation year, 25 (23.6 %) resulted positive for DS-Ab production. During a 2-year follow up only 12 of the 81 FCXM-negative patients (14.8 %) suffered rejection vs 17 of 25 FCXM-positive patients (68 %; P = 0.00 001). Correlating graft loss to DS-Ab production, 9 FCXM-positive patients lost the graft vs only 1 among the FCXM-negative patients. A worse graft function was evidenced in FCXM-positive subjects who had also suffered rejection episodes than in those which had acute rejection but did not produce DS-Abs. A high incidence of HLA-AB mismatches was found in FCXM-positive subjects which produced anti-class I antibodies. FCXM appears useful in estimating posttransplant alloimmune response. Moreover our findings confirm the harmful effects of anti-class I DS-Abs on long-term graft survival.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1432-2277
    Keywords: Key words HLA class I matching ; Cadaveric renal transplant ; Crossreactive antigens (CREG) ; Flow cytometric crossmatch (FCXM) ; Anti-HLA alloantibodies
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Donor-recipient HLA matching was retrospectively evaluated in 111 cadaveric renal transplants using Takemoto's ten-residue model in which HLA class I antigens are clustered by crossreactive group (CREGs) on the basis of amino acid sequence homology and the sharing of a particular public epitope. The grade and type of HLA residue mismatching were correlated to posttransplant, class I donor-specific antibody production (monitored by flow cytometry crossmatch), rejection occurrence and clinical outcome during the 1st year posttransplant. In 52 patients with 0 mismatchings (MMs) we observed a low incidence of rejection (11.1 %) and antibody production (11.1 %) for 0 CREG MM grade, while 1 MM was enough to increase immune response against graft (rejection 35 %; antibodies 30 %). Moreover, a significant correlation was observed between Q144, E163, Q62 and L82/R82 epitopes and the incidence of acute rejection and antibody production (“immunogenic” residues) in patients grouped for a single residue mismatch.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1590-3478
    Keywords: Multiple sclerosis ; T8+cells ; T-cells analysis ; T-cells during clinical phase of MS ; T-lymphocyte subsets ; monoclonal antibodies ; T-cell subsets ; T8+lymphocytes ; blood T-lymphocytes ; lymphocyte subsets
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Sommario Una analisi seriale delle sottopopolazioni T-linfocitarie del sangue periferico è stata eseguita in 280 campioni prelevati in un periodo di 27 mesi da 14 pazienti affetti da Sclerosi Multipla. Una riduzione significativa delle cellule T8+ è stata trovata nel 47,1% (41/87) dei campioni ematici prelevati durante le quattro settimane dopo l'insorgenza della recidiva rispetto al 2,1% (1/47) dei campioni prelevati durante le quattro settimane prima di una recidiva e rispetto al 3,4% (5/146) di quelli prelevati oltre quattro settimane dopo una recidiva. Le variazioni delle sottopopolazioni delle cellule T sembrano correlarsi con l'attività della malattia, ma i valori normali osservati prima delle recidive suggeriscono che la riduzione delle cellule T8+ non può essere usata come un valido predittore delle recidive.
    Notes: Abstract Serial analyses of peripheral blood T-lymphocyte subsets were performed in 280 samples collected over a 27 months period from 14 multiple sclerosis patients. A significant decrease of T8+ cells was found in 47.1% (47/87) of blood samples collected within four weeks of onset of a relapse opposed to 2.1% (1/47) of samples collected during the four weeks before a relapse and to 3.4% (5/146) of those collected over four weeks after a relapse. Changes of T-cells subsets appear to correlate with disease activity, but normal findings observed before relapses suggest that the decrease of T8+ cells cannot be used as valid predictor of relapse.
    Type of Medium: Electronic Resource
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