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  • 1
    Electronic Resource
    Electronic Resource
    Late cranial MRI after cranial irradiation in survivors of childhood cancer (1994)
    Springer
    Neuroradiology 36 (1994), S. 652-655 
    Details
    ISSN: 1432-1920
    Keywords: Brain ; Magnetic resonance imaging ; Acute lymphoblastic leukaemia ; Radiotherapy ; Meningioma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We carried out MRI on 43 survivors of childhood cancer after different treatment protocols with or without cranial radiotherapy. They were free of disease, therapy having been discontinued 2–20 years earlier. Treatment had been for various malignancies, excluding brain tumours; 27 had received cranial irradiation for acute lymphoblastic leukaemia (ALL) or lymphoma. Two asymptomatic young women treated for ALL had falx meningiomas. White matter changes, low intensity foci (representing calcification or old haemorrhage) and heterogeneous intensity focic old haemorrhages) were seen only in patients who had undergone radiotherapy. Because of the possibility of benign, potentially curable brain tumours occurring after cranial irradiation, it may be wise to carry out occasional cranial imaging in the follow-up of these patients. No routine imaging follow-up is needed after chemotherapy alone.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00600433
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Growth impairment and growth hormone therapy in children treated for malignant brain tumours (1997)
    Springer
    European journal of pediatrics 156 (1997), S. 764-769 
    Details
    ISSN: 1432-1076
    Keywords: Key words Brain tumours ; Radiotherapy ; Late effects ; Growth hormone therapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Eighty-two children with malignant brain tumours were treated according to the “8 in 1” chemotherapy protocol in Finland during 1986 to 1993. Thirty-seven with brain tumours not involving the hypothalamic-pituitary region are still alive and tumour-free. The growth and response to growth hormone (GH) therapy in these children was analysed. Children who received craniospinal irradiation had the most severe loss of height SDS, being −1.07 within 3 years of the diagnosis. Even children with no irradiation to the hypothalamic-pituitary axis had a mean change in height SDS of −0.5 after 3 years. Fifteen of 23 children who received craniospinal irradiation and two out of eight children who received cranial irradiation have received GH therapy. A catch-up growth response to the daily GH therapy with the mean dose of 0.7 IU/kg per week was complete in 3 years (+1.87 SDS), irrespective of craniospinal irradiation, in children who were treated at prepubertal age but was seen in none of the children who had reached pubertal age. Conclusion Growth impairment and GH deficiency are common in children treated for malignant brain tumours. The response to GH therapy is good in prepubertal children in terms of increased growth velocity, although the final height is not yet known.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004310050708
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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