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  • 1
    Electronic Resource
    Electronic Resource
    Cockayne's syndrome (1970)
    Springer
    European journal of pediatrics 109 (1970), S. 70-75 
    Details
    ISSN: 1432-1076
    Keywords: Deafness ; Cockayne's Syndrome ; Retinal Degeneration
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Ein siebenjähriger Knabe mit dem Syndrom Cockayne mit Taubheit, der retinalen „Salz und Pfeffer”-Degeneration, Mikrocephalus, Wachstumsverzögerung und dem abnormalen Aussehen, aber mit einer normalen Intelligenz. Dieses läßt annehmen, daß die mentale Retardierung nicht absolut zu dem Syndrom gehört.
    Notes: Abstract The patient discussed is a seven year old boy with Cockayne's syndrome, deafness, retinal “salt and pepper”-like abnormalities, microcephaly, retarded growth and abnormal appearance, but normal intelligence. This suggests that mental retardation is not inevitably associated with Cockayne's syndrome.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00443496
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  • 2
    Electronic Resource
    Electronic Resource
    Rapid intravenous immunoglobulin infusions in children with idiopathic thrombocytopenic purpura (1994)
    Springer
    European journal of pediatrics 153 (1994), S. 862-862 
    Details
    ISSN: 1432-1076
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01972900
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  • 3
    Electronic Resource
    Electronic Resource
    Growth impairment and growth hormone therapy in children treated for malignant brain tumours (1997)
    Springer
    European journal of pediatrics 156 (1997), S. 764-769 
    Details
    ISSN: 1432-1076
    Keywords: Key words Brain tumours ; Radiotherapy ; Late effects ; Growth hormone therapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Eighty-two children with malignant brain tumours were treated according to the “8 in 1” chemotherapy protocol in Finland during 1986 to 1993. Thirty-seven with brain tumours not involving the hypothalamic-pituitary region are still alive and tumour-free. The growth and response to growth hormone (GH) therapy in these children was analysed. Children who received craniospinal irradiation had the most severe loss of height SDS, being −1.07 within 3 years of the diagnosis. Even children with no irradiation to the hypothalamic-pituitary axis had a mean change in height SDS of −0.5 after 3 years. Fifteen of 23 children who received craniospinal irradiation and two out of eight children who received cranial irradiation have received GH therapy. A catch-up growth response to the daily GH therapy with the mean dose of 0.7 IU/kg per week was complete in 3 years (+1.87 SDS), irrespective of craniospinal irradiation, in children who were treated at prepubertal age but was seen in none of the children who had reached pubertal age. Conclusion Growth impairment and GH deficiency are common in children treated for malignant brain tumours. The response to GH therapy is good in prepubertal children in terms of increased growth velocity, although the final height is not yet known.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004310050708
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  • 4
    Electronic Resource
    Electronic Resource
    Aminoterminal propeptide of type III procollagen in cerebrospinal fluid. Variation with age and in childhood leukemia
    Amsterdam : Elsevier
    Clinica Chimica Acta 203 (1991), S. 47-56 
    Details
    ISSN: 0009-8981
    Keywords: Acute lymphoblastic leukemia ; Arachnoid ; Corticosteroids ; Fibroproliferative response ; Intraspinal injections ; Methotrexate
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0009-8981(91)90155-6
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  • 5
    Electronic Resource
    Electronic Resource
    Lymphocyte Blast Transformation Responses in Measles Infection (1980)
    Oxford, UK : Blackwell Publishing Ltd
    Scandinavian journal of immunology 12 (1980), S. 0 
    Details
    ISSN: 1365-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Lymphocyte blast transformation responses were studied in eight patients with natural measles infection. A specific response to purified measles virus antigen and a weaker response to crude measles virus antigen were found after infection. The response to purified measles antigen appeared 1–3 weeks after the beginning of the rash, when the great number of proliferating mononuclear cells found in the peripheral blood during the rash was declining. In the first weeks after onset of the rash also leucocyte and lymphocyte numbers were decreased, and specific responses to purified tuberculin (PPD) and to rubella and mumps virus antigens were suppressed. In mitogen stimulation tests there was no significant suppression of phytohaemagglutinin and concanavalin responses in this small series, but the response to pokeweed mitogen was decreased. The responses to antigens other than measles virus antigens recovered in parallel with the increase of the measles-specific response.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-3083.1980.tb00082.x
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  • 6
    Electronic Resource
    Electronic Resource
    Crystalline Fc prepared in High Yield from Normal Human IgG (1970)
    [s.l.] : Nature Publishing Group
    Nature 226 (1970), S. 356-358 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Human IgG was prepared from the serum of single Caucasian individuals by DEAE-cellulose chromatography3, and checked for purity by immunoelectrophoresis. In preliminary experiments, an IgG which contained an anti-D rhesus agglutinin was used to indicate approximately the conditions necessary for ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/226356b0
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  • 7
    Electronic Resource
    Electronic Resource
    Late cranial MRI after cranial irradiation in survivors of childhood cancer (1994)
    Springer
    Neuroradiology 36 (1994), S. 652-655 
    Details
    ISSN: 1432-1920
    Keywords: Brain ; Magnetic resonance imaging ; Acute lymphoblastic leukaemia ; Radiotherapy ; Meningioma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We carried out MRI on 43 survivors of childhood cancer after different treatment protocols with or without cranial radiotherapy. They were free of disease, therapy having been discontinued 2–20 years earlier. Treatment had been for various malignancies, excluding brain tumours; 27 had received cranial irradiation for acute lymphoblastic leukaemia (ALL) or lymphoma. Two asymptomatic young women treated for ALL had falx meningiomas. White matter changes, low intensity foci (representing calcification or old haemorrhage) and heterogeneous intensity focic old haemorrhages) were seen only in patients who had undergone radiotherapy. Because of the possibility of benign, potentially curable brain tumours occurring after cranial irradiation, it may be wise to carry out occasional cranial imaging in the follow-up of these patients. No routine imaging follow-up is needed after chemotherapy alone.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00600433
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  • 8
    Electronic Resource
    Electronic Resource
    General lymphangiomatosis in a child (1978)
    Springer
    Pediatric radiology 7 (1978), S. 49-50 
    Details
    ISSN: 1432-1998
    Keywords: Generalised lymphangiomatosis ; Lymphatic dysplasia ; Lymphography ; Retroperitoneal tumour
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The lymphographic findings in a 4 year old girl with general lymphangiomatosis are presented. The number of iliac and lumbar lymphatics had increased markedly and the lymph nodes were enlarged with very loose structure and with contrast medium distributed in scattered droplets and filiform channels.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00975338
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  • 9
    Electronic Resource
    Electronic Resource
    Minor changes on cranial MRI during treatment in children with acute lymphoblastic leukaemia (1996)
    Springer
    Neuroradiology 38 (1996), S. 264-268 
    Details
    ISSN: 1432-1920
    Keywords: Acute lymphoblastic leukaemia ; Magnetic resonance imaging ; Brain, children ; Leukoencephalopathy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Cranial MRI was used to study treatment-related changes in children undergoing therapy for acute lymphoblastic leukaemia (ALL) or lymphoma. Nineteen children (18 with ALL, 1 with lymphoma) underwent MRI at the beginning of treatment and at intervals during it, to a total of 105 imaging studies and a minimum of 3 per case. Nine patients had finished all therapy, all received consolidation treatment. No patient had central nervous system (CNS) leukaemia at diagnosis or developed a CNS relapse. Mild treatment-related white matter changes were observed in only 2 patients after consolidation therapy with three 5 g/m2 pulses of intravenous methotrexate. Transient enlargement of the ventricles and cortical sulci was observed in 13 patients, always temporally related to steroid treatment. These preliminary data suggest that treatment-related white matter changes are rare and no routine MRI follow-up is needed during treatment in asymptomatic children after a baseline assessment.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00596544
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  • 10
    Electronic Resource
    Electronic Resource
    Minor changes on cranial MRI during treatment in children with acute lymphoblastic leukaemia (1996)
    Springer
    Neuroradiology 38 (1996), S. 264-268 
    Details
    ISSN: 1432-1920
    Keywords: Key words Acute lymphoblastic leukaemia ; Magnetic resonance imaging ; Brain ; children ; Leukoencephalopathy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Cranial MRI was used to study treatment-related changes in children undergoing therapy for acute lymphoblastic leukaemia (ALL) or lymphoma. Nineteen children (18 with ALL, 1 with lymphoma) underwent MRI at the beginning of treatment and at intervals during it, to a total of 105 imaging studies and a minimum of 3 per case. Nine patients had finished all therapy, all received consolidation treatment. No patient had central nervous system (CNS) leukaemia at diagnosis or developed a CNS relapse. Mild treatment-related white matter changes were observed in only 2 patients after consolidation therapy with three 5 g/m2 pulses of intravenous methotrexate. Transient enlargement of the ventricles and cortical sulci was observed in 13 patients, always temporally related to steroid treatment. These preliminary data suggest that treatment-related white matter changes are rare and no routine MRI follow-up is needed during treatment in asymptomatic children after a baseline assessment.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00596544
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    Paper (German National Licenses)
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