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  • Spleen  (2)
  • Relapse  (1)
  • finite volume method  (1)
  • 1
    Electronic Resource
    Electronic Resource
    The role of splenectomy in the treatment of relapsing thrombotic thrombocytopenic purpura (1995)
    Springer
    Annals of hematology 70 (1995), S. 231-236 
    Details
    ISSN: 1432-0584
    Keywords: Thrombotic thrombocytopenic purpura Relapse ; Splenectomy ; Spleen
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Thrombotic thrombocytopenic purpura (TTP) is a serious disorder of unknown etiology. Clinical findings are the result of vascular occlusions by platelet aggregates. Treatment with plasma exchange, often used in combination with corticosteroids, vincristine, aspirin, and dipyridamole, has reduced mortality to 20%. Relapses may occur even after long disease-free intervals. In this report we describe our experience with splenectomy in patients with relapsing TTP. Between July 1978 and March 1994, 16 patients with TTP were treated in our hospital. Five of the 13 patients surviving the first episode of TTP had relapses. Most relapses were treated as the first episode of TTP with plasma exchange with fresh-frozen plasma, followed by plasma infusions, corticosteroids, and vincristine. Sometimes aspirin and dipyridamole were added. Splenectomy was performed after five relapses in the first two patients and after two and three relapses in the other patients. Before splenectomy the disease-free interval varied from 3 weeks to 27 months and the incidence rate of relapses was 1.5 relapse/patient/year. None of the patients had relapses after splenectomy. The mean follow-up after splenectomy is 39 months with a range of 9–62 months. We conclude that patients with relapsing TTP can benefit from splenectomy, since it seems to increase disease-free intervals. Further investigation is necessary to understand the role of the spleen in the pathogenesis of TTP.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01784041
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    The role of splenectomy in the treatment of relapsing thrombotic thrombocytopenic purpura (1995)
    Springer
    Annals of hematology 70 (1995), S. 231-236 
    Details
    ISSN: 1432-0584
    Keywords: Key words Thrombotic thrombocytopenic purpura ; Relapse ; Splenectomy ; Spleen
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Thrombotic thrombocytopenic purpura (TTP) is a serious disorder of unknown etiology. Clinical findings are the result of vascular occlusions by platelet aggregates. Treatment with plasma exchange, often used in combination with corticosteroids, vincristine, aspirin, and dipyridamole, has reduced mortality to 20%. Relapses may occur even after long disease-free intervals. In this report we describe our experience with splenectomy in patients with relapsing TTP. Between July 1978 and March 1994, 16 patients with TTP were treated in our hospital. Five of the 13 patients surviving the first episode of TTP had relapses. Most relapses were treated as the first episode of TTP with plasma exchange with fresh-frozen plasma, followed by plasma infusions, corticosteroids, and vincristine. Sometimes aspirin and dipyridamole were added. Splenectomy was performed after five relapses in the first two patients and after two and three relapses in the other patients. Before splenectomy the disease-free interval varied from 3 weeks to 27 months and the incidence rate of relapses was 1.5 relapse/patient/year. None of the patients had relapses after splenectomy. The mean follow-up after splenectomy is 39 months with a range of 9–62 months. We conclude that patients with relapsing TTP can benefit from splenectomy, since it seems to increase disease-free intervals. Further investigation is necessary to understand the role of the spleen in the pathogenesis of TTP.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01784041
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Simulation of vortex shedding past a square cylinder with different turbulence models (1998)
    Chichester : Wiley-Blackwell
    International Journal for Numerical Methods in Fluids 28 (1998), S. 601-616 
    Details
    ISSN: 0271-2091
    Keywords: turbulence modeling ; CFD ; finite volume method ; vortex shedding ; two-layer approach ; Engineering ; Numerical Methods and Modeling
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: This paper presents the results of numerical simulations of vortex shedding past a free-standing square cylinder at ReD=22 000, obtained with different turbulence models. Using wall functions, the standard k-ε model is compared with a modification suggested by Kato and Launder (Proc. 9th Symp. Turbulent Shear Flows, Kyoto, 10-4-1 (1993)). In addition, both versions are used in a two-layer approach, in which the flow close to the cylinder is computed with a locally more suitable one-equation turbulence model and only outside the viscous near-wall layer with the two mentioned high-Re model versions. To allow a comparison, the simulations are performed first using the same computational domain and boundary conditions as in previous investigations. Then results are presented that were obtained on a computational domain and with boundary conditions more suitable for a comparison with the experiments. © 1998 John Wiley & Sons, Ltd.
    Additional Material: 9 Ill.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
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