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  • 1
    Electronic Resource
    Electronic Resource
    Etonitazene as a reinforcer: Oral intake of etonitazene by rhesus monkeys (1978)
    Springer
    Psychopharmacology 59 (1978), S. 225-229 
    Details
    ISSN: 1432-2072
    Keywords: Rhesus monkeys ; Etonitazene HCl ; Etonitazene concentration ; Etonitazene reinforcement ; Fixed-ratio schedules ; Etonitazene drinking ; Oral self-administration
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Drinking of etonitazene HCl was studied in three rhesus monkeys during daily 3-h sessions. As the drug concentration was increased, the number of liquid deliveries decreased, and etonitazene intake (μg/kg body weight) increased. As fixed-ratio (FR) requirements were increased, rate of responding increased, and liquid deliveries slightly decreased. When water was substituted for the drug, there was a large increase in responding for several sessions, followed by a slow decline to low rates. When etonitazene was reintroduced, responding abruptly increased to previous drug levels. These data suggest that etonitazene can serve as a positive reinforcer when taken orally by rhesus monkeys.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00426626
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Ethanol drinking by rhesus monkeys as a function of concentration (1978)
    Springer
    Psychopharmacology 57 (1978), S. 133-136 
    Details
    ISSN: 1432-2072
    Keywords: Rhesus monkeys ; Ethanol reinforcement ; Ethanol concentration ; Blood ethanol level ; Ethanol drinking ; Fixed-ratio schedules ; Intoxication
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Ethanol deliveries maintained fixed-ratio (FR) responding of three rhesus monkeys during daily 3-h sessions. At FR values of 8 or 16, ethanol concentration was varied in the sequence 0 (water), 8, 11.3, 16, 22.6, 32, 8, and 0% (w/v). As the ethanol concentration increased, number of liquid deliveries decreased, although intake of ethanol (g/kg/session) increased somewhat. Blood ethanol levels were usually greater than 200 mg% and occasionally greater than 300 mg%.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00426877
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Concurrent pentobarbital- and saccharin-maintained responding: effects of saccharin concentration and schedule conditions (1993)
    Springer
    Psychopharmacology 112 (1993), S. 204-210 
    Details
    ISSN: 1432-2072
    Keywords: Alternative reinforcer ; Concurrent schedules ; Signaled differential reinforcement of low rates ; DRL ; Drug reinforcement ; Mutually exclusive options ; Oral drug self-administration ; Pentobarbital ; Rhesus monkeys ; Saccharin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Responses of rhesus monkeys were reinforced by delivery of either a pentobarbital (4.0 mg/ml) solution or a vehicle (water) or saccharin solution under a concurrent signaled differential reinforcement of low rates 30-s schedule. After 30 s of no responding, the first response on the pentobarbital or saccharin spout resulted in the delivery of the appropriate solution and reset the timing on both spouts (i.e. a mutually exclusive choice). In the first experiment, the concentration of saccharin was gradually increased across sessions. As saccharin concentration increased, pentobarbital deliveries decreased and saccharin as well as total session deliveries increased. In a second experiment, pentobarbital and 0.24 (mg/ml) saccharin were made available under concurrent signaled differential reinforcement of low rates 30-s schedules which operated independently. Under these conditions responding on one spout had no consequences with respect to the other spout. The reduction of pentobarbital deliveries was substantially attenuated when the choice was not mutually exclusive.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02244912
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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