ISSN:
1590-3478
Keywords:
cerebrospinal fluid
;
peripheral blood
;
T-cells
;
helper/suppressor ratio
;
multiple sclerosis bouts
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Description / Table of Contents:
Sommario Sono state studiate con anticorpi monoclonali le sottopopolazioni linfocitarie (T-totali, T-helper e T-suppressor) ematiche e liquorali in 18 pazienti con sclerosi multipla e 4 con malattie neurologiche non infiammatorie. Non è stata trovata alcuna differenza del rapporto helper/suppressor nel sangue in varie fasi della malattia, mentre un aumento del rapporto helper/suppressor nel liquor è stato riscontrato nelle riesacerbazioni. I risultati confermano la compartimentalizzazione delle anomalie della risposta immunitaria nella sclerosi multipla.
Notes:
Abstract Enumeration of cerebrospinal fluid and peripheral blood T-lymphocyte subsets (T-total, T-helper and T-suppressor) was performed by monoclonal antibody technique in 18 patients with Multiple Sclerosis and in 4 patients with non-inflammatory neurological diseases. While no differences were observed in peripheral blood subsets among the various phases of the disease, a marked rise in cerebrospinal fluid helper-suppressor ratio was seen in acute relapses. The results give further support to the concept of a strict compartimentalization in immune response abnormalities in Multiple Sclerosis patients.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02335734
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