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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Molecular and cellular biochemistry 91 (1989), S. 85-90 
    ISSN: 1573-4919
    Keywords: liposome ; aspergillosis ; mannose ; amphotericin-B
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Abstract The efficacy and toxicity of free and liposome intercalated amphotericin-B (Amp-B) in controlling Aspergillosis, caused byAspergillus fumigatus in BALB/c mice were studied. Liposomal Amp-B had higher LD50 (8.1 mg/kg) as compared to that of the free drug (1.2 mg/kg). An improvement in the therapeutic index of the drug was observed with liposomal formulation of the drug. We also focussed on the effect of lipid composition and surface sugar in modulating the therapeutic potency of Amp-B. The most effective liposomal preparation was composed of egg phosphatidylcholine (EPC) : L-α-phosphatidylethanolamine, dipalmitoyl (DPPE): cholesterol (Chol) in the molar ratio of 6:1:3. Amp-B intercalated into mannose grafted liposomes (LD50 = 9.3 mg/kg) was more effective as compared to the other formulation tested.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Water, air & soil pollution 85 (1995), S. 2137-2142 
    ISSN: 1573-2932
    Keywords: Wet-only ; Bulk samples ; Neutralization factors ; Soil
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering
    Notes: Abstract Rain water samples were collected at New Delhi during the monsoon of 1994 at a height of 30 m above the ground level using a wet-only collector. Simultaneously, bulk samples from two different heights at 30 m and 13 m were collected. Frequency distribution of pH in wet-only samples revealed that rain was mostly alkaline Four out of 23 events were observed to be acidic where the ratio of (Ca+Mg+NH4)/(SO4+NO3) was very low. pH and ionic constituents were higher in bulk samples than in wet-only samples. On an average, the concentration in bulk samples at 30m height exceeded the wet-only samples by 13% while bulk samples collected at 13m height had 19% higher concentration than the bulk samples at 30m height and 32% higher than wet-only. The acidity of ram water was mainly contributed by sulphuric acid rather than nitric acid. At the height of 30 m, the acidity was primarily neutralized by NH4 while at 13 m height, it was buffered by Ca and Mg indicating the influence of dust particles.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
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