ISSN:
0170-2041
Keywords:
Macrolides
;
Antibiotics
;
Fungicides
;
Sorangium cellulosum
;
Myxobacteria
;
Soraphen
;
Calculations, MMX force field
;
Chemistry
;
Organic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
From the myxobacterium Sorangium cellulosum, strain So ce26, a novel group of highly active antifungal metabolites was isolated. Large-scale production of the basic compound soraphen A1α (1) was achieved by fermentation in the presence of the adsorber resin XAD-16, extraction and crystallization. The 18-membered macrolide structure of 1 was determined by spectroscopic methods. X-ray crystal structure analysis revealed the absolute configuration of the ten asymmetric centers. According to proton coupling constants and difference NOE measurements the solution conformation in CDCl3 and [D6]DMSO is very similar to that in the crystal structure.
Additional Material:
3 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/jlac.1993199301161
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