ISSN:
1432-5233
Keywords:
Pancreatic islet
;
Insulin secretion
;
Formycin A
;
Goto-Kakizaki rat
;
Streptozotocin
;
Succinic acid dimethyl ester
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Pancreatic islets isolated from control rats, Goto-Kakizaki rats and adult rats that were injected with streptozotocin during the neonatal period were incubated for two successive periods of 90 min each in the presence ofd-glucose (11.1 mM) with or without formycin A (1.0 mM), and in the presence of the dimethyl ester of succinic acid (SAD, 10.0 mM) with or without palmitate (1.0 mM). Although formycin A augmented glucose-stimulated insulin release in both control and diabetic rats, it failed to compensate for the impaired secretory response tod-glucose in the latter animals. Likewise, non-glucidic nutrients such as SAD and/or palmitate failed to display a more efficient insulinotropic action, relative to basal insulin output, in diabetic than control rats. These results indicate that both formycin A and non-glucidic nutrients are unable, through their immediate insulinotropic action, to restore a normal output of insulin in islets of animals with inherited or acquired non-insulin-dependent diabetes.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00838492
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