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Digitale Medien

PAPS-cerebroside sulphotransferase activity in developing brain of a neurological mutant of mouse (msd) (1974)

Sarlieve, L. L. ; Neskovic, N. M. ; Rebel, G. ; [weitere]

Springer

Experimental brain research 19 (1974), S. 158-165

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Details

ISSN: 1432-1106

Schlagwort(e): Myelin deficiency ; Mutant mice (msd) ; Sulphatide synthesis ; Cerebroside sulphotransferase ; Developmental changes

Quelle: Springer Online Journal Archives 1860-2000

Thema: Medizin

Notizen: Summary 1. The activity of the sulphotransferase involved in the synthesis of sulphatides, 3′-phosphoadenosine-5′-phosphosulphate cerebroside sulphotransferase (PAPS-CST), was determined in the developing CNS of the myelin synthesis deficiency mutant mouse (msd) and compared to that in control animals. There was a decrease of the PAPS-CST activity in msd mouse in the period from 8 to 26 days. The developmental curve of PAPS-CST activity in msd mice brains essentially paralleled that in normal animals, with a maximum at about 19 days. 2. Basic enzyme properties, such as Km, optimum pH, and heat inactivation, were not affected by the mutation.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF00238532

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