ISSN:
1432-1335
Keywords:
Thymoma
;
Histological classification
;
Ultrastructural pathology
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Fifty-seven thymomas, defined as neoplasms of the epithelial-reticular framework cells of the thymus, were assessed in respect to histologic type, inclusive of there ultrastructural aspects. The median age of the 57 patients was 40.4 years, with a range of 2 1/2–72 years. All neoplasms were located in the anterior mediastinum. The tumours in 40 cases were encapsulated and without invasion of adjacent tissue or implants (= non-invasive thymomas). The tumors in 17 cases were invasive of adjacent tissue, particularly mediastinal pleura, pericard and trachea. Six of 57 patients (= 10.5%) with thymomas have had a thoracic and supraclavicular lymph node metastasis, and osteolytic metastases in the vertebrae and sternum. Thirty-seven (=64.9%) were so-called lympho-epithelial, 7 (=12.3%) pure epithelial, 4 (= 7.0%) atypical (or anaplastic) with granulomatous focuses, 3 (= 5.3%) carcinoid and one (=1.8%) seminomatous tumors. One patient have had a thymic cyst as a tumor-like conditions of the thymus, and four patients (= 7.0%) have had a thymo-lipoma. The histologie type of thymoma had no proof value in predicting prognosis with the exception of the so-called atypical or anaplastic thymoma. The fine structural aspects of thymomas and the fine structural differential diagnosis of anterior mediastinal tumors are discussed.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00305975
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