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  • Titanium graphite  (1)
  • helioseismology  (1)
  • plasma clearance  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Global Oscillations at Low Frequency from the SOHO mission (GOLF) (1995)
    Springer
    Solar physics 162 (1995), S. 61-99 
    Details
    ISSN: 1573-093X
    Keywords: sun ; helioseismology
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract The GOLF experiment on the SOHO mission aims to study the internal structure of the sun by measuring the spectrum of global oscillations in the frequency range 10−7 to 10−2 Hz. Bothp andg mode oscillations will be investigated, with the emphasis on the low order long period waves which penetrate the solar core. The instrument employs an extension to space of the proven ground-based technique for measuring the mean line-of-sight velocity of the viewed solar surface. By avoiding the atmospheric disturbances experienced from the ground, and choosing a non-eclipsing orbit, GOLF aims to improve the instrumental sensitivity limit by an order of magnitude to 1 mm s−1 over 20 days for frequencies higher than 2.10−4 Hz. A sodium vapour resonance cell is used in a longitudinal magnetic field to sample the two wings of the solar absorption line. The addition of a small modulating field component enables the slope of the wings to be measured. This provides not only an internal calibration of the instrument sensitivity, but also offers a further possibility to recognise, and correct for, the solar background signal produced by the effects of solar magnetically active regions. The use of an additional rotating polariser enables measurement of the mean solar line-of-sight magnetic field, as a secondary objective.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00733427
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    The role of the liver in the clearance ofl-dopa from plasma (1975)
    Springer
    Journal of pharmacokinetics and pharmacodynamics 3 (1975), S. 13-23 
    Details
    ISSN: 1573-8744
    Keywords: l-dopa ; plasma half-life ; plasma clearance ; total body clearance ; hepatic clearance
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract The role of the liver in the plasma clearance of l-dopa in the rat was examined. Some published studies which ascribe an important role to the liver in l-dopa clearance are discussed and critically evaluated. Contrary evidence suggesting that the liver is not a significant site of l-dopa clearance in vivo ispresented. The plasma concentration of l-dopa during intravenous infusion of the drug was not significantly reduced after a single passage through the liver. All of the data discussed are consistent with the conclusion that the liver plays a minor role in l-dopa clearance in vivo.It is suggested that the small intestine is the major site of metabolism of orally administered l-dopa.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01066592
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Syntheses of Zindoxifene and Analogues by Titanium-Induced Oxo-Amide Coupling (1994)
    Weinheim : Wiley-Blackwell
    Berichte der deutschen chemischen Gesellschaft 127 (1994), S. 1125-1130 
    Details
    ISSN: 0009-2940
    Keywords: Indoles, 2-aryl- ; Titanium graphite ; Zindoxifene ; Tumor-growth inhibitors ; Alkylidenation, intramolecular ; Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Highly reactive titanium on graphite is used to reductively cyclize electron-rich acylamino carbonyl compounds 7, 8, 12, 14, and 16 to the corresponding indole derivatives 9, 10, 13, 15, and 17. Compound 9b is a known precursor of the mammary tumor-inhibiting compound zindoxifene (2). The other products are new analogues of this anticancer drug, exhibiting the substitution pattern previously recognized to be essential for high pharmacological activity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/cber.19941270624
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    Paper (German National Licenses)
    Fulltext
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