ISSN:
1432-0584
Keywords:
Translocation (14,18) and (8,22)
;
Leukemia
;
NHL
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Three patients with centrocytic/centroblastic lymphoma developed a rapidly fatal leukemic transformation of the disease after a transient remission. At the time of transformation, cytogenetic analysis revealed in all patients abnormal karyotypes with coexistence of t (14; 18) and t (8; 22). Molecular analysis in one patient showed rearrangement of the BCL2 oncogene and c-myc m-RNA expression. These findings imply that translocation t (14; 18) was present during the first phase of the disease and that acquisition of translocation t (8; 22) was accompanied by leukemic transformation.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01698379
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