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  • 1
    Electronic Resource
    Electronic Resource
    Differential modulation of cisplatin accumulation in leukocytes and tumor cell lines by the paclitaxel vehicle Cremophor EL (1997)
    Springer
    Annals of oncology 8 (1997), S. 1145-1150 
    Details
    ISSN: 1569-8041
    Keywords: cisplatin ; Cremophor EL ; drug accumulation ; haematopoietic cells ; leukocytes ; paclitaxel
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background: Several clinical studies have shown that poly-chemotherapy with the taxanes paclitaxel or docetaxel preceded or followed by cisplatin is associated with important schedule-dependent differences in toxicities, such as leukocytopenia. In general, the pharmacokinetics of both drugs during the combined treatment are unaltered, suggesting that a pharmacodynamic interaction might have occurred. Materials and methods: In order to gain insight into this pharmacologic interaction, we performed in vitro drug accumulation studies using peripheral blood leukocytes and a panel of tumor and non-malignant cell lines with paclitaxel and docetaxel, as wel as with their respective formulation vehicles Cremophor EL and Tween 80. Results: Our results show a significant reduction in the intracellular cisplatin concentration in leukocytes of up to 42% in the presence of Cremophor EL and Tween 80 as compared to the control. This pharmacodynamic interaction of these surfactants with cisplatin seems to be specific for haematopoietic cells, and does not occur in solid tumor cells. Conclusion: The present data suggest that the pharmaceutical vehicles Cremophor EL and Tween 80 might contribute to the reduced cisplatin-associated myelotoxicity observed in the clinical combination chemotherapy studies with paclitaxel and docetaxel.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1008215720081
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Determination of polar pollutants in water using an on-line liquid chromatographic preconcentration system (1991)
    Springer
    Chromatographia 32 (1991), S. 445-452 
    Details
    ISSN: 1612-1112
    Keywords: Column liquid chromatography ; On-line preconcentration ; Polar pollutants ; Water (tap and surface)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Summary An isocratic column liquid chromatographic system with UV absorbance detection at 230 nm has been developed for the rapid trace-level determination of a large number of polar pollutants in water. The systems contains two precolumns, in series, which are packed with a styrenedivinylbenzene (PLRP-S) polymer. The second precolumn is also loaded with sodium dodecylsulphate before use. Each precolumn is combined with a PLRP-S analytical column, and aqueous acetonitrile mixtures (pH 3) are used for the separation of neutral as well as acidic and basic pollutants. With 10-ml water samples the detection limits for all analytes, in tap water, are in the low to sub μg/l range. Relevant analytical data are reported and the advantage of using a dodecylsulphate-loaded precolumn over a cation-exchange precolumn is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02327976
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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