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  • 1
    Electronic Resource
    Electronic Resource
    Distribution of sister chromatid exchanges in different types of chromatin in the X chromosome ofMicrotus cabrerae (1996)
    Springer
    Cellular and molecular life sciences 52 (1996), S. 511-515 
    Details
    ISSN: 1420-9071
    Keywords: Sister chromatid exchanges (SCEs) ; Microtus cabrerae ; X chromosome ; chromatin structure
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract We used the X chromosomes ofMicrotus cabrerae as a model to analyze the distribution of sister chromatid exchanges (SCEs) on different types of chromatin, because of the marked heterogeneity of the heterochromatin in the entire short arm and a portion of the long arm of this chromosome. Computer-simulated distributions, according to an algorithm that makes it possible to modify the distribution on the basis of any possible hypothesis, were compared with real distributions by log-linear models. We found that the frequency of SCEs in different types of heterochromatin was higher than that expected for a random distribution, and located an SCE hot-spot at the junction between euchromatin and heterochromatin. The possible relationship between the distribution of SCEs and base composition or chromatin accessibility are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01969719
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Inactive ribosomal cistrons are spread throughout the B chromosomes of Rattus rattus (Rodentia, Muridae). Implications for their origin and evolution (2000)
    Springer
    Chromosome research 8 (2000), S. 305-311 
    Details
    ISSN: 1573-6849
    Keywords: B-chromosomes ; black rat ; NORs ; rDNA ; supernumerary chromosomes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract In-situ hybridization with a rDNA probe has demonstrated the presence of non-transcribed ribosomal genes in the B chromosomes of the black rat Rattus rattus. To test whether methylation of ribosomal DNA present in the B chromosomes could account for their inactivation, we performed in-situ digestions and Southern analyses of DNA digested with the isoschizomers MspI and HpaII. Our results suggest that the accessory chromosomes of this species have originated from one of the smaller NOR-carrying chromosome pairs. In the course of evolution, repetitive sequences invaded this supernumerary element and its ribosomal DNA content was dispersed throughout the chromosome and inactivated by heterochromatinization and methylation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1009227427575
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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