ISSN:
1438-2199
Keywords:
Picolinic acid
;
Quinolinic acid
;
Zinc
;
Excitotoxicity
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary This study examined whether picolinic acid (PIC) inhibits quinolinic acid (QUIN) — induced excitotoxicity through zinc chelation. Injection of QUIN into the nucleus basalis magnocellularis significantly depleted cortical choline acetyltransferase activity 7 days post injection and PIC inhibited this response. Zinc augmented the QUIN- but not NMDA-induced response. When PIC was co-administered with zinc, PIC failed to attenuate the QUIN-induced response. The inhibition of QUIN — induced cholinergic toxicity by PIC may involve chelation of zinc.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01345272
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