ISSN:
1573-8221
Keywords:
prethrombins 1 and 2
;
anticlotting system
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Abstract Prethrombin 2, the direct precursor of thrombin, was obtained by restricted proteolysis of prethrombin 1 by trypsin or by active factor X. In the absence of enzymes, prethrombin 1 is not converted into prethrombin 2. Factor V was shown not to affect the rate of thrombin generation from prethrombin 2. It was shown that prethrombin 2 has no intrinsic coagulating or esterase activity. After intravenous injection of preparations of prethrombin 2, the plasma recalcification time was lengthened and total fibrinolytic activity and nonenzymic fibrinolysis were increased. A considerable increase also was found in the activity of the fibrinogen-heparin complex. These results are evidence of excitation of the anticlotting system by intravenous injection of small doses of prethrombin 2.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00834219
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