ISSN:
1432-1041
Keywords:
asthma
;
beta2-adrenoceptor agonist
;
isoprenaline iontophoresis
;
beta2-adrenoceptor
;
terbutaline
;
corticosteroids
;
dermal blood vessels
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
,
Medicine
Notes:
Summary Peripheral β-adrenoceptor reactivity, measured as the dermal erythematous reaction to iontophoretically administered isoprenaline was studied in 41 asthmatics, 13 patients with allergic rhinoconjunctivitis and 21 healthy control subjects. The response of intact superficial dermal blood vessels to isoprenaline, which has previously been demonstrated to be β 2-adrenoceptor mediated, was reduced in asthmatics treated with high dose, oral, slow-release β 2-agonists compared to healthy controls. The response in asthmatics not treated with oral β 2-agonists and in patients with allergic rhinoconjunctivitis did not differ from controls. Thus, the peripheral β 2-adrenergic rectivity of intact human superficial blood vessels is affected by oral, slow-release β 2-agonists.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00542486
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