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  • 1
    Electronic Resource
    Electronic Resource
    Increased peripheral α-adrenoceptor response in allergic asthmatics (1988)
    Oxford, UK : Blackwell Publishing Ltd
    Allergy 43 (1988), S. 0 
    Details
    ISSN: 1398-9995
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The peripheral α-adrenoceptor reactivity, measured as dermal blanching response to iontophoretically administered phenylephrine, was studied in 28 allergic asthmatics, 13 patients with allergic rhinoconjunctivitis and 21 healthy controls. The blanching response, which has previously been demonstrated to be mediated via α1-adrenoceptors, was found to be significantly increased in allergic asthmatics compared with controls. It is suggested that there is an increased peripheral α-adrenoceptor reactivity in allergic asthma.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1398-9995.1988.tb02043.x
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  • 2
    Electronic Resource
    Electronic Resource
    Effects of chronic stimulation of salivary gland β-adrenoceptors on saliva composition and caries development in the rat (1989)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of oral pathology & medicine 18 (1989), S. 0 
    Details
    ISSN: 1600-0714
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The effects of long-term β-adrenoceptor stimulation or inhibition on parotid and submandibular glands, saliva secretion, and caries development were studied. Groups of rats were treated daily with: 0.5 or 5 mg/kg body weight of isoproterenol (IPR), 0.5 or 5 mg/kg bw propranolol (PRO), or saline. After 42 days, saliva was collected and analyzed for secretion rate, total protein, amylase, sialic acid and electrolytes. Total protein and amylase in saliva decreased and potassium increased in the high IPR group. Phosphate increased in both IPR groups and decreased in the high PRO group. The average weight of parotid glands increased 3.7 times in the high IPR group and 1.8 times in the low IPR group. Amylase and total protein in parotid gland extracts decreased in both IPR groups. The submandibular gland weight increased 1.5 times in the high IPR group. Total protein decreased in the high IPR group. There was no difference in caries development.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0714.1989.tb01357.x
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  • 3
    Electronic Resource
    Electronic Resource
    Erythema elevatum diutinum-a case successfully treated with colchicine (1989)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental dermatology 14 (1989), S. 0 
    Details
    ISSN: 1365-2230
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2230.1989.tb02611.x
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  • 4
    Electronic Resource
    Electronic Resource
    Adrenoceptor-mediated responses in human skin studied by iontophoresis (1984)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 111 (1984), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The adrenoceptor-mediated responses in human skin (bnlanching and erythema) were studied by an iontophoretic technique. It is concluded that the receptors in superficial dermal blood vessels belong to the subclasses α1 and β2.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.1984.tb06625.x
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  • 5
    Electronic Resource
    Electronic Resource
    Fluoroalcohols-XXVI. Vibrational spectra of pentafluoroprop-1-en-2-ol (enolic pentafluoroacetone)
    Amsterdam : Elsevier
    Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy Section 36 (1980), S. 607-609 
    Details
    ISSN: 0584-8539
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0584-8539(80)80016-X
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  • 6
    Electronic Resource
    Electronic Resource
    Interleukin-2-induced growth inhibition of prostatic adenocarcinoma (Dunning R 3327) in rats (1992)
    Springer
    Urological research 20 (1992), S. 189-191 
    Details
    ISSN: 1434-0879
    Keywords: Interleukin-2 ; Prostatic carcinoma ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The present study was designed to evaluate the effect of a biological response modifier, interleukin-2 (IL-2), on the growth in rats of Dunning (R3327, androgen sensitive) prostatic adenocarcinoma. IL-2 was given to one group of tumour-bearing rats by subcutaneous infusion (Alzet micro-osmotic pump 2002, 14 days) of 424,286 IU/kg per day during 4 weeks. Another group was shamoperated and served as control. Tumour growth was calculated by weekly measurement of tumour volume. IL-2 treatment caused a significant growth delay without any significant toxicity. Plasma testosterone concentrations were similar in both groups and ventral prostatic weights did not differ. Morphometric analyses of epithelial cells, stroma, luminal compartment in tumour tissue and calculation of the number of intratumoral lymphocytes did not show any differences between the two groups. It is suggested that IL-2 treatment can decrease prostatic tumour growth without apparently affecting the testosterone metabolism. Further studies with special interest on the mechanism of action are justified.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00299715
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  • 7
    Electronic Resource
    Electronic Resource
    Decreased peripheral β-adrenergic reactivity in asthmatics treated with oral β 2-agonists (1988)
    Springer
    European journal of clinical pharmacology 33 (1988), S. 557-560 
    Details
    ISSN: 1432-1041
    Keywords: asthma ; beta2-adrenoceptor agonist ; isoprenaline iontophoresis ; beta2-adrenoceptor ; terbutaline ; corticosteroids ; dermal blood vessels
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Peripheral β-adrenoceptor reactivity, measured as the dermal erythematous reaction to iontophoretically administered isoprenaline was studied in 41 asthmatics, 13 patients with allergic rhinoconjunctivitis and 21 healthy control subjects. The response of intact superficial dermal blood vessels to isoprenaline, which has previously been demonstrated to be β 2-adrenoceptor mediated, was reduced in asthmatics treated with high dose, oral, slow-release β 2-agonists compared to healthy controls. The response in asthmatics not treated with oral β 2-agonists and in patients with allergic rhinoconjunctivitis did not differ from controls. Thus, the peripheral β 2-adrenergic rectivity of intact human superficial blood vessels is affected by oral, slow-release β 2-agonists.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00542486
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  • 8
    Electronic Resource
    Electronic Resource
    Effects of Amifostine on Cisplatin Induced DNA Adduct Formation and Toxicity in Malignant Glioma and Normal Tissues in Rat (1999)
    Springer
    Journal of neuro-oncology 42 (1999), S. 13-21 
    Details
    ISSN: 1573-7373
    Keywords: glioma ; chemotherapy ; cisplatin ; amifostine ; DNA adducts
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The chemoprotective effect of amifostine (WR2721) was studied in a BDIX rat model with intracerebral BT4C glioma implants. Twenty-one rats were given cisplatin 5 mg/kg i.p., 21 were given amifostine 200 mg/kg i.p.+cisplatin 5 mg/kg i.p. Ten rats served as untreated controls. An immunohistochemical method for analysis of cisplatin–DNA adducts was used to elucidate the adduct formation in tumor, normal brain and kidney. Tumor volume and serum creatinine level were analysed 10 days after treatment. In animals pretreated with amifostine there was a delayed adduct formation rate in the normal brain, and in the kidney cortex the number of tubular cells with extremely high adduct level was reduced. No difference in adduct formation was seen in tumors. Tumor volume was significantly larger following amifostine+cisplatin (66% of controls) compared to cisplatin alone (38% of controls). Weight loss was, however, severe in rats given cisplatin alone. In the tumor growth study only 3 out of 11 rats treated with cisplatin 5 mg/kg alone survived until time of sacrifice at 10 days, whereas all those pretreated with amifostine survived. Mean serum creatinine was 48 µmol/l (controls), 146 µmol/l (cisplatin) and 59 µmol/l (amifostine+cisplatin). A marked reduction of histopathological renal changes was found when amifostine was added. Amifostine thus significantly reduced general and renal toxicity of cisplatin. The tumor growth retardation was stronger when cisplatin was given alone but this is probably related to general toxicity and malnutrition indirectly supported by the fact that amifostine did not significantly reduce cisplatin–DNA adduct formation in tumors. The results of the present study suggest that amifostine may have a role in increasing the therapeutic ratio of cisplatin, also in the treatment of malignant glioma.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1006152103476
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  • 9
    Electronic Resource
    Electronic Resource
    Structural changes in the middle ear tissues of the rat after fractionated irradiation (1993)
    Springer
    European archives of oto-rhino-laryngology and head & neck 250 (1993), S. 92-96 
    Details
    ISSN: 1434-4726
    Keywords: Middle ear ; Pars flaccida ; Fractionated irradiation ; Keratinizing epithelium ; Macrophages
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Chronic suppurative otitis media often ensues in patients treated with irradiation against a head and neck tumor. In an experimental study, rats were exposed to irradiation to evaluate the sensitivity of the middle ear to an accumulated irradiation dose of 20–45 Gy. Observed otomicroscopically, all animals appeared to have normal tympanic membranes and no fluid developed in the middle ear space. Ten days after the irradiation, minor structural changes had occurred in the pars flaccida. The keratinizing epithelium had thickened and mitoses were seen histologically. The lamina propria was edematous and contained polymorphonuclear cells and macrophages. The middle ear mucosa from all other tissue sites appeared normal. Six months after irradiation only minor changes in the pars flaccida were evident: the lamina propria was thin and inelastic and macrophages were present in the stroma. It is inferred from this study that the middle ear of the rat is relatively resistant to irradiation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00179305
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