ISSN:
1573-904X
Keywords:
tissue engineering
;
growth factors
;
controlled release
;
bone
;
nerve
;
liver
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Abstract A tissue-engineered implant is a biologic-biomaterial combination in which some component of tissuehas been combined with a biomaterial to create a device for the restoration or modification of tissue ororgan function. Specific growth factors, released from a delivery device or from co-transplanted cells,would aid in the induction of host paraenchymal cell infiltration and improve engraftment of co-deliveredcells for more efficient tissue regeneration or ameliorate disease states. The characteristic properties ofgrowth factors are described to provide a biological basis for their use in tissue engineered devices. Theprinciples of polymeric device development for therapeutic growth factor delivery in the context of tissueengineering are outlined. A review of experimental evidence illustrates examples of growth factor deliveryfrom devices such as micropaticles, scaffolds, and encapsulated cells, for their use in the applicationareas of musculoskeletal tissue, neural tissue, and hepatic tissue.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1023/A:1007502828372
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