ISSN:
1573-4927
Keywords:
mice
;
subspecies
;
homeo box
;
c-myc oncogene
;
linkage test
;
restriction fragment length variation (RFLV)
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Chemistry and Pharmacology
Notes:
Abstract Restriction endonuclease fragment length variations (RFLV) were detected by use of the cDNA probeHox-3.1 for the homeo box-3.1 gene and also thec-myc oncogene probe for exon 2. RFLV ofHox-3.1 were found inHindIII restriction patterns, and RFLV of theMyc-1.2 gene inEcoRV patterns. From the RFLV, theHox-3.1 andMyc-1.2 genes were mapped on chromosome 15. Three-point cross test data showed that the frequency of recombination is 26.4% betweenMyc-1.2 andGpt-1, 30.2% betweenGpt-1 andGdc-1, and 9.4% betweenGdc-1 andHox-3.1. The following order of these genes is proposed,Myc-1.2—Gpt-1—Gdc-1—Hox-3.1. All laboratory strains carry theHox-3.1 a andMyc-1.2 a alleles. Among strains of wild origin,domesticus strains carry only theHox-3.1 a andMyc-1.2 a alleles, as do the laboratory strains. One strain ofbrevirostris carries theHox-3.1 a andMyc-1.2 b alleles. Other wild subspecies from Europe and Asia,M. m. musculus, M. m. castaneus, M. m. molossinus, Chinese mice of wild origin, andM. m. yamashinai carry theHox-3.1 b andMyc-1.2 b alleles.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00554083
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