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Digitale Medien

Carbamazepine and its 10,11-epoxide in children and adults with epilepsy (1977)

Pynnönen, S. ; Sillanpää, M. ; Frey, H. ; [weitere]

Springer

European journal of clinical pharmacology 11 (1977), S. 129-133

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Details

ISSN: 1432-1041

Schlagwort(e): carbamazepine ; carbamazepine-10,11-epoxide ; plasma concentration ; CSF concentration ; children ; adult

Quelle: Springer Online Journal Archives 1860-2000

Thema: Chemie und Pharmazie , Medizin

Notizen: Summary The plasma concentrations of carbamazepine and its 10,11-epoxide were measured in 37 children and 13 adults with epilepsy during maintenance therapy. The children formed relatively more of the epoxy metabolite than adults. The daily dose, expressed as mg/kg or mg/m2, showed a statistically significant correlation with blood level in children, but not in adults. The cerebrospinal fluid concentrations of carbamazepine and carbamazepine-10,11-epoxide in nine children were 33 and 41 per cent, respectively, of the concomitant plasma level.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF00562904

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