Electronic Resource
Springer
Digestive diseases and sciences
34 (1989), S. 1365-1368
ISSN:
1573-2568
Keywords:
gastrointestinal motility
;
gastrointestinal hormones
;
substance P
;
bombesin
;
cholecystokinin
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Dose—response characteristics of feline corpus circular muscle were studiedin vitro for three neuropeptides individually and with vasoactive intestinal peptide. Bombesin, substance P, and cholecystokinin-octapeptide each elicited concentration-dependent isometric contractions that were reduced by 10−8 M or 10−7 M vasoactive intestinal peptide (P〈0.01). The concentration of each neuropeptide producing a half-maximal response was increased more than one logfold to ≥10−6 M by vasoactive intestinal peptide. Tetrodotoxin blocked responses to bombesin (P〈0.001) and reduced responses to substance P (P〈0.05), but had no effect on responses to cholecystokinin-octapeptide (P〉0.1). These results demonstrate inhibition of neuropeptide responses of gastric smooth muscle and support vasoactive intestinal peptide as an inhibitory regulator of gastric motor function.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01538070
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