ISSN:
1420-9071
Keywords:
Genetic code
;
directional mutation pressure
;
GC-content
;
unassigned codon
;
tRNA
;
codon capture
;
codon usage
;
Mycoplasma
;
mitochondria
;
Micrococcus
;
methanogens
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Summary The prokaryotic genetic code has been influenced by directional mutation pressure (GC/AT pressure) that has been exerted on the entire genome. This pressure affects the synonymous codon choice, the amino acid composition of proteins and tRNA anticodons. Unassigned codons would have been produced in bacteria with extremely high GC or AT genomes by deleting certain codons and the corresponding tRNAs. A high AT pressure together with genomic economization led to a change in assignment of the UGA codon, from stop to tryptophan, inMycoplasma.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01936919
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