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Digitale Medien

Prospective comparative study in NIDDM patients of metformin and glibenclamide with special reference to lipid profiles (1991)

Hermann, L. S. ; Karlsson, J -E. ; Sjöstrand, Å.

Springer

European journal of clinical pharmacology 41 (1991), S. 263-265

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Details

ISSN: 1432-1041

Schlagwort(e): Metformin ; Glibenclamide ; NIDDM ; lipoproteins ; C-peptide ; diabetes mellitus ; adverse effects ; serum lipids

Quelle: Springer Online Journal Archives 1860-2000

Thema: Chemie und Pharmazie , Medizin

Notizen: Summary. Twenty-two NIDDM patients completed an open randomized cross-over study comparing metformin and glibenclamide over 1 year. The drugs had an equivalent effect on glycaemic control, but, in contrast to glibenclamide, metformin reduced body weight. Neither drug affected triglycerides, total-and LDL-cholesterol or C-peptide. Metformin caused a slight elevation of HDL-cholesterol (P 〈 0.05). No serious adverse effects were observed. The results show that oral hypoglycaemic agents are not associated with undesirable effects on lipids and lipoproteins.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF00315441

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