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  • pharmacokinetics  (2)
  • diabetic control  (1)
  • diabetic pregnancy  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Glycosylated haemoglobin in cord blood following normal and diabetic pregnancies (1983)
    Springer
    Diabetologia 25 (1983), S. 482-485 
    Details
    ISSN: 1432-0428
    Keywords: Glycosylated haemoglobin ; cord blood ; diabetic pregnancy ; normal pregnancy ; diabetes ; pregnancy ; diabetic control
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Cord and maternal blood samples were obtained at delivery in 25 normal and 14 diabetic pregnancies (13 insulindependent, one gestational). Total glycosylated haemoglobin, measured by the colorimetric thiobarbiturate method (mmol hydroxymethylfurfural/mol haemoglobin), was lower in cord than maternal blood (mean 18.7±1.7 versus 26.5±2.1, mean ± SD, p〈0.001). Glycosylated haemoglobin was higher following diabetic pregnancies, both in cord (diabetic 19.9± 1.6 versus normal 17.9±1.4, p〈0.001) and maternal samples (diabetic 27.7±1.5 versus normal 25.6±2.1, p〈0.005). Cord and maternal glycosylated haemoglobin correlated in the normal (r=0.60, p〈0.01) but not in the diabetic group (r=0.02, NS). Birth weight ratio was higher in infants of diabetic than of normal mothers (1.10±0.16 versus 0.99±0.13, p〈 0.05) but failed to correlate with cord or maternal glycosylated haemoglobin or, in the diabetic group, with mean blood glucose.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00284455
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    The disposition of meptazinol after single and multiple intravenous administration to pregnant and non-pregnant women (1989)
    Springer
    European journal of clinical pharmacology 36 (1989), S. 273-277 
    Details
    ISSN: 1432-1041
    Keywords: meptazinol ; pregnant and non-pregnant women ; pharmacokinetics ; single and repeated i.v. dosing
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary We have studied the disposition of the centrally-acting analgesic meptazinol in a group of age-matched non-pregnant and pregnant (36–38 weeks gestation) women. Ten non-pregnant and nine multiparous pregnant volunteers each received a single i.v. dose of meptazinol hydrochloride (equivalent to 25 mg base). A further group of 9 non-pregnant (including four of the original participants) and 10 multiparous pregnant subjects were given repeated i.v. doses of meptazinol hydrochloride (each equivalent to 10 mg base) at 30-min intervals for 2.5 h. Meptazinol plasma concentrations were determined by HPLC using fluorescence detection and the pharmacokinetic variables investigated. After single dosing there were no statistical differences in half-life, clearance, or apparent volume of distribution between the two groups, suggesting that the disposition of meptazinol was not altered by pregnancy. This was confirmed in the repeated dose study, in which no significant differences occurred in either the plasma concentrations achieved or in areas under the curves between the non-pregnant and pregnant subjects. Furthermore, the steady-state concentrations were comparable with those predicted from the single dose results. This indicates that there should be no requirement for dosage alteration of meptazinol during pregnancy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00558159
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Biliary secretion of felodipine metabolites in man after intravenous [14C]felodipine (1990)
    Springer
    European journal of clinical pharmacology 38 (1990), S. 421-424 
    Details
    ISSN: 1432-1041
    Keywords: felodipine ; bile ; dihydropyridines ; biliary secretion ; healthy volunteers ; drug metabolism ; pharmacokinetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The biliary secretion of [14C]felodipine in 4 healthy human subjects was studied by use of the multiple marker dilution principle with double lumen tubes placed in the stomach and intestine. Insignificant amounts of14C activity were recovered from gastric aspirates. The individual recovery from intestinal aspirates varied from 2.9 to 8.5% of the dose of radioactivity over the period of 4.5 h after dosing. Less than 0.1% was identified as unchanged felodipine. The results show that biliary secretion is a minor route of elimination of felodipine or its metabolites. Bile collection for 4.5 h had no significant effect on the pharmacokinetics of felodipine, although the 72 h urinary recovery of radioactivity tended to be lower when bile was collected (59%) than in the control experiment (66%).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02336677
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    Paper (German National Licenses)
    Fulltext
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