ISSN:
0006-3592
Keywords:
Catharanthus roseus
;
ajmalicine production rate
;
dissolved oxygen concentration
;
kinetic model
;
high-density culture
;
Chemistry
;
Biochemistry and Biotechnology
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Biology
,
Process Engineering, Biotechnology, Nutrition Technology
Notes:
The relation between dissolved oxygen (DO) and the ajmalicine production rate of Catharanthus roseus was investigated in 15-L tank reactors at constant stirrer speed and gas flow rate. Below a DO concentration of 29% of air saturation the ajmalicine production rate was less than 0.06 μmol/g/d. Above a DO of 43% the ajmalicine production rate was constant at 0.21 μmol/g/d. Between a DO of 29% and 43% there was a strong relation between the ajmalicine production rate and the DO concentration. After a period of at least 12 days at DO ≤29% the culture lacked the ability to adapt to a DO ≥57%. A kinetic equation is proposed for the relation between DO and the specific ajmalicine production rate. © 1995 John Wiley & Sons, Inc.
Additional Material:
4 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/bit.260450508
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