ISSN:
1573-8744
Keywords:
ethanol
;
volume of distribution
;
Michaelis-Menten elimination kinetics
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Abstract The novel method of estimating the volume of distribution involves (a) administering an appropriate bolus intravenous dose of the drug, (b) starting a constant-rate intravenous infusion of the drug at the same time, (c) maintaining the infusion for a given number of hours, (a) measuring the drug concentration over the entire time course, (e) computer-fitting the post-infusion data to obtain estimates of Vm and Km, (f) estimating the total area under the concentration-time curve from zero time to infinity, and (g) iteratively solving a cubic equation to obtain the estimate of the volume of distribution. The method was applied to ethanol in the cat and yielded an average value of 635ml/kg (63.5% of body weight) with a coefficient of variation of 23.0%. This is equivalent to total body water in the cat.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01312262
Permalink
