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  • forest clearing  (1)
  • polyamines  (1)
  • 1
    ISSN: 1573-7217
    Keywords: breast cancer ; erythrocytes ; polyamines ; prognosis ; urine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Polyamines are involved in the development of breast cancer. We assayed polyamines in erythrocytes, urines, and breast tissues (tumor tissue and histologically normal breast tissue close to the tumor) of patients with invasive breast cancer (n=174) and benign breast disease (n=71, used as controls). Polyamine levels in red blood cells and urine were similar to the polyamine concentrations found in healthy subjects, and thus cannot be used as diagnostic markers of breast cancer. In cancer tissue, polyamines were significantly increased in comparison with the polyamine concentrations in controls, and were correlated to the tumor aggressiveness as evaluated by histological grade and Ki-67 proliferative index. On the other hand, correlation was found between polyamine levels in the tumor and the status of the hormone receptors. In the mammary tissue close to the cancer, polyamines dramatically decreased in comparison with the polyamine levels of tissue samples removed around the histologically proven benign tumors. The changes of the polyamine concentrations in the histologically normal breast tissue in the vicinity of the cancer could play a role in the cancer development and need further studies, especially if polyamines are considered as a potential therapeutic target in breastcancer.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1573-5036
    Keywords: 13C isotope ; changes in soil ; forest clearing ; maize crop ; soil organic carbon
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Abstract In southwest France, sandy spodosols have developed from Quaternary sandy eolian deposits. On these soils, numerous forest lands have been converted to continuous intensive maize cropping. A chronosequence study is realized by comparing organic C pools and 13C natural abundance of one forested and 6 agricultural sites, whose ages of cultivation range from 4 to 32 yr. δ13C ratio is found to increase with time of cultivation. After 3 decades of intensive maize cropping, about half of the initial organic C content in the forest topsoil layer has disappeared. The fraction of C derived from maize crop increases during the first decades of cultivation, but its level is significantly lower than those observed in other soils, which indicates a high mineralization rate of organic C. In this context, soil characteristics associated to intensive agricultural practices lead to a rapid and large loss of C, whereas inputs from maize seem to have only a very small long-term contribution.
    Type of Medium: Electronic Resource
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