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  • 1
    Electronic Resource
    Electronic Resource
    Polyamine profiles in tumor, normal tissue of the homologous breast, blood, and urine of breast cancer sufferers (2000)
    Springer
    Breast cancer research and treatment 60 (2000), S. 99-105 
    Details
    ISSN: 1573-7217
    Keywords: breast cancer ; erythrocytes ; polyamines ; prognosis ; urine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Polyamines are involved in the development of breast cancer. We assayed polyamines in erythrocytes, urines, and breast tissues (tumor tissue and histologically normal breast tissue close to the tumor) of patients with invasive breast cancer (n=174) and benign breast disease (n=71, used as controls). Polyamine levels in red blood cells and urine were similar to the polyamine concentrations found in healthy subjects, and thus cannot be used as diagnostic markers of breast cancer. In cancer tissue, polyamines were significantly increased in comparison with the polyamine concentrations in controls, and were correlated to the tumor aggressiveness as evaluated by histological grade and Ki-67 proliferative index. On the other hand, correlation was found between polyamine levels in the tumor and the status of the hormone receptors. In the mammary tissue close to the cancer, polyamines dramatically decreased in comparison with the polyamine levels of tissue samples removed around the histologically proven benign tumors. The changes of the polyamine concentrations in the histologically normal breast tissue in the vicinity of the cancer could play a role in the cancer development and need further studies, especially if polyamines are considered as a potential therapeutic target in breastcancer.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1006319818530
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  • 2
    Electronic Resource
    Electronic Resource
    Analysis of the Proenkephalin Second Messenger-Inducible Enhancer in Rat Striatal Cultures (1995)
    Oxford, UK : Blackwell Science Ltd
    Journal of neurochemistry 65 (1995), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: We have previously shown that in cell extracts from rat striatum, cyclic AMP response element (CRE) binding protein (CREB), rather than AP-1 proteins, preferentially interacts with the CRE-2 element of the proenkephalin second messenger-inducible enhancer, even under conditions in which AP-1 proteins are highly induced. Here we use primary striatal cultures to permit a more detailed analysis of CRE-2 function and protein binding in relevant neural cell types. By transfection we find that in primary striatal cultures, as in transformed cell lines, the CRE-1 and CRE-2 elements are required for significant induction by cyclic AMP. We report that cyclic AMP induction of the proenkephalin gene in striatal cultures is protein synthesis independent, excluding a role for newly synthesized proteins like c-Fos. We also show that cyclic AMP induces CREB phosphorylation and that phosphorylated CREB interacts strongly with CRE-2 and weakly with CRE-1. The predominant protein bound to CRE-1 is not CREB, however, and remains to be identified. Despite some prior predictions, we do not find a role for c-Fos in cyclic AMP regulation of proenkephalin gene expression in neurons.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1471-4159.1995.65031007.x
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  • 3
    Electronic Resource
    Electronic Resource
    On the use of the checker-board test to assess the resolution of tomographic inversions (1993)
    Oxford, UK : Blackwell Publishing Ltd
    Geophysical journal international 115 (1993), S. 0 
    Details
    ISSN: 1365-246X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Geosciences
    Notes: This note is devoted to the confrontation of intuitive ideas in the field of inverse problems, especially in tomographic seismological studies, with the results of a more rigorous approach. With the help of a simple example, we show that tests commonly used to illustrate the quality of inversion results can be misleading. Based on a classical mathematical analysis, we explain the origin of the problems that we have seen. Our main conclusion is that, in circumstances not so unrealistic, and in contradiction to a generally idea, small-size structures like in the ‘checker-board test’ can be well retrieved while larger structures are poorly retrieved.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-246X.1993.tb05605.x
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  • 4
    Electronic Resource
    Electronic Resource
    On a New Collar Ciliate of a Gribble: Lobochona prorates n. sp. on Limnoria tripunctata (1963)
    Oxford, UK : Blackwell Publishing Ltd
    The @journal of eukaryotic microbiology 10 (1963), S. 0 
    Details
    ISSN: 1550-7408
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: SYNOPSIS. Lobochona prorates n. sp., a collar cliate (CHONOTRICHIDA) ectocommensal on the pleopodal bristles of Limnoria tripunctata, is described. Lobochona prorates differs from the previously described chonotrichidan ectocommensal of the gribble, Lobochona limnoriae Dons on Limnoria lignorum (Rathke), in the outlines of the body and of the marginal lappets of the collar. The genus Lobochona Dons and the species Lobochona limnoriae Dons are redescribed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1550-7408.1963.tb01667.x
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  • 5
    Electronic Resource
    Electronic Resource
    Physical Methods for Skin Investigation (1983)
    Oxford, UK : Blackwell Publishing Ltd
    International journal of dermatology 22 (1983), S. 0 
    Details
    ISSN: 1365-4632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-4362.1983.tb01209.x
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  • 6
    Electronic Resource
    Electronic Resource
    The “Haptic Finger”– a new device for monitoring skin condition (2003)
    Oxford, UK : Munksgaard International Publishers
    Skin research and technology 9 (2003), S. 0 
    Details
    ISSN: 1600-0846
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background/aims: Touching the skin is of great importance for the Clinician for assessing roughness, softness, firmness, etc. This type of clinical assessment is very subjective and therefore non-reproducible from one Clinician to another one or even from time to time for the same Clinician. In order to objectively monitor skin texture, we developed a new sensor, placed directly on the Clinician's finger, which generate some electric signal when slid over the skin surface.Material and methods: The base of this Haptic Finger sensor is a thin stainless steel plate on which sponge rubber, PVDF foil, acetate film and gauze are layered. The signal generated by the sensor was filtered and digitally stored before processing. In a first in vitro experiment, the sensor was moved over different skin models (sponge rubber covered by silicon rubber) of varying hardness and roughness. These experiments allowed the definition of two parameters characterizing textures. The first parameter is variance of the signal processed using wavelet analysis, representing an index of roughness. The second parameter is dispersion of the power spectrum density in the frequency domain, corresponding to hardness. To validate these parameters, the Haptic Finger was used to scan skin surfaces of 30 people, 14 of whom displayed a skin disorder: xerosis (n = 5), atopic dermatitis (n = 7), and psoriasis (n = 2).Results and conclusion: The results obtained by means of the sensor were compared with subjective, clinical evaluations by a Clinician who scored both roughness and hardness of the skin. Good agreement was observed between clinical assessment of the skin and the two parameters generated using the Haptic Finger. Use of this sensor could prove extremely valuable in cosmetic research where skin surface texture (in terms of tactile properties) is difficult to measure.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1034/j.1600-0846.2003.00031.x
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  • 7
    Electronic Resource
    Electronic Resource
    Professor Pierre Agache (2004)
    Oxford, UK : Munksgaard International Publishers
    Skin research and technology 10 (2004), S. 0 
    Details
    ISSN: 1600-0846
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0846.2004.00073.x
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  • 8
    Electronic Resource
    Electronic Resource
    SkinChip®, a new tool for investigating the skin surface in vivo (2003)
    Oxford, UK : Munksgaard International Publishers
    Skin research and technology 9 (2003), S. 0 
    Details
    ISSN: 1600-0846
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background/aims: Non-invasive methods used for characterizing skin micro-relief and skin surface hydration were developed in the 1980s. Although they allowed some progress in the knowledge of skin properties, they are not completely satisfactory in many aspects. Today, new technologies are emerging that may address such issues.Methods: We adapted the technology produced by the ST Microelectronics Company for sensing fingerprint for the measurement of skin surface properties. Accordingly, we developed acquisition software for obtaining routinely the distribution of skin surface capacitance along different body sites. Image analysis softwares were also processed for collecting both the main orientations of the micro-relief lines and their density. The average value of skin capacitance is also obtained.Results: The images allow a highly precise observation of the skin topography that can be easily quantified in terms of line density and line orientation. The mean gray levels of the images appear much closely correlated to the Corneometer values.Conclusion: This new device appears to be a very convenient way for characterizing the properties of the skin surface. With regard to hydration, it usefully provides both the average value and the hydration chart of the investigated skin zones.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1034/j.1600-0846.2003.00043.x
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  • 9
    Electronic Resource
    Electronic Resource
    Organization of Stratum Corneum Lipids in Relation to Permeability: Influence of Sodium Lauryl Sulfate and Preheating (1994)
    Springer
    Pharmaceutical research 11 (1994), S. 1414-1418 
    Details
    ISSN: 1573-904X
    Keywords: stratum corneum ; lipid organization ; permeability ; sodium lauryl sulfate ; preheating
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract The role of the structural organization of intercorneocyte lipids in the barrier function of human stratum corneum was evaluated by treatment with heat and sodium lauryl sulfate. Measurement of transepidermal water loss in treated samples was used to quantify variations in stratum corneum permeability. Thermodynamic transition of lamellar lipids and their degree of organization were evaluated by differential scanning calorimetry and small-angle X-ray diffraction, respectively. Progressively preheating stratum corneum samples from 75°C to 90°C increased stratum corneum permeability to water vapor, while the fusion temperature of lamellar lipids and the intensity of the X-ray diffraction peaks of the polar lipids decreased. Sodium lauryl sulfate induced similar variations of these three parameters. These results support the hypothesis that, in addition to the chemical nature of intercorneocyte lipids, their structural arrangement and thermodynamic properties play an important role in the barrier function of the stratum corneum to water vapor.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1018987721531
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  • 10
    Electronic Resource
    Electronic Resource
    Soil organic carbon dynamics in cleared temperate forest spodosols converted to maize cropping (1997)
    Springer
    Plant and soil 191 (1997), S. 225-231 
    Details
    ISSN: 1573-5036
    Keywords: 13C isotope ; changes in soil ; forest clearing ; maize crop ; soil organic carbon
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Abstract In southwest France, sandy spodosols have developed from Quaternary sandy eolian deposits. On these soils, numerous forest lands have been converted to continuous intensive maize cropping. A chronosequence study is realized by comparing organic C pools and 13C natural abundance of one forested and 6 agricultural sites, whose ages of cultivation range from 4 to 32 yr. δ13C ratio is found to increase with time of cultivation. After 3 decades of intensive maize cropping, about half of the initial organic C content in the forest topsoil layer has disappeared. The fraction of C derived from maize crop increases during the first decades of cultivation, but its level is significantly lower than those observed in other soils, which indicates a high mineralization rate of organic C. In this context, soil characteristics associated to intensive agricultural practices lead to a rapid and large loss of C, whereas inputs from maize seem to have only a very small long-term contribution.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1004294822799
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