ISSN:
1432-1041
Keywords:
acetylsalicylic acid
;
adverse drug reaction
;
gastrointestinal bleeding
;
upper gastrointestinal ulcerative disease
;
duodenal ulcer
;
gastric ulcer
;
erosive gastritis
;
hospital drug monitoring
;
inpatients
;
NSAID
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
,
Medicine
Notes:
Summary The hospital prevalence rate for upper gastrointestinal ulcerative disease in 28,531 inpatients consecutively admitted in two teaching hospitals in the Comprehensive Hospital Drug Monitoring (CHDM) in Berne, from 1974 to 1985, was 2.2% (1.8% for gastric or duodenal ulcer, and 0.4% for erosive gastritis). This was based on the evaluation of 634 patients after exclusion of the subgroup of patients with hepatic cirrhosis or upper gastrointestinal neoplasia. After exclusion of patients on anticoagulant therapy (n=73), 561 (=100%) patients could be further studied. Of them, 33.3% (n=187) were found to have been exposed to non-steroidal anti-inflammatory drugs (NSAIDs), including aspirin, within 21 days prior to confirmation of the diagnosis. The observed relative risk (RR) of developing a substantial acute upper gastrointestinal bleeding (Hb 〈 10 g/100 ml for men, and 〈9 g/100 ml for women, or a decrease in Hb of more than 25%) was 1.61 when patients exposed to NSAIDs (n=187) were compared to patients not exposed to those drugs (n=374). Although there was no significant sex difference overall, the RR for gastrointestinal bleeding differed considerably in the various age-groups; it was elevated in men under 40 years (RR=2.86) and in women over 60 years of age (RR=1.89), as compared to the mean RR of 1.61.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00314799
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